Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1995-05-16
1998-11-10
Cunningham, Thomas M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4242781, 424 934, 530350, 530395, A61K 3904
Patent
active
058339965
ABSTRACT:
Immunoregulatory material derived from Mycobacterium vaccae, especially dead cells of M. vaccae, are useful for the treatment of pathological conditions (other than mycobacterial disease and arthritic disease) in a patient in which the patient's IgG shows an abnormally high proportion of agalactosyl IgG and for the treatment of chronic inflammatory disorders (other than an arthritic disease) caused or accompanied by an abnormally high release from macrophages of interleukin-6 and/or tumor necrosis factor.
REFERENCES:
patent: 4404194 (1983-09-01), Arala-Chaves
patent: 4716038 (1987-12-01), Stanford et al.
patent: 4724144 (1988-02-01), Rook et al.
patent: 5114844 (1992-05-01), Cohen et al.
patent: 5599545 (1997-02-01), Stanford et al.
Kim, M.S. et al., EMBASE abstract 76115069 of Korean J. Dermatol. 13(1):25-31, "Therapeutic trial of BCG in patients with psoriasis", 1975.
Braude, et al. Infections Disease and Medical Microbiology (2nd ed.) (1986), pp. 364-371.
Coltran, et al. Robbins Pathelogical Basis of Disease, (1989), 4th edition, pp. 1299-1301.
Fillex, E, et al., Clin. Exp. Immunol., 76; 343-347 (Jun. 1989), "A transient n5e in agalactosyl lgG correlating with Free tL-2 receptors . . ."
Parekh, R. B. et al. Nature 316:452-457 (1985), "Association of rheumatoid arthritis and primary osteo-arthritis with changes in the glycosylation pattern of total serum lgG".
Wand-Wurftenberger A et al. Eur. J. Immunol. 21:1089-1092 (1991), "Surface expression by mononuclear Phagocytes of an epitope shared with mycobacterial hsp 65.".
Racemacher, T.W. et al. Springer Semin. Immunopathology 10:231-49 (1988) "Role of IgG Glycoforms in the Pathogenesis of Rheumatoid Arthritis."
Rook Graham Arthur William
Stanford John Lawson
Cunningham Thomas M.
University College London
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