Treatment of protozoal diseases

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Para-n-benzene - sulfoxy-n containing doai – and said benzene...

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514155, 514158, 514272, A61K 31505, A61K 3165, A61K 31255

Patent

active

052739708

ABSTRACT:
The antibacterial substance baquiloprim (2,4-diamino-5-[8-dimethylamino-7-methyl-5-quinolylmethyl]pyrimidine) is shown to be active against protozoal infections, e.g. toxoplasmosis. Preferably the baquiloprim is administered together with a sulphonamide.

REFERENCES:
patent: 3969520 (1976-07-01), Garzia
patent: 4587342 (1986-05-01), Daluge et al.
patent: 4761475 (1988-08-01), Daluge et al.
Burchall and Hitchings, "Inhibitor Binding Analysis of Dihydrofolate Reductases from Various Species," Mol. Pharmacol. 1, 126-136 (1965).
Hitchings and Bushby Proc. 5th Int. Cong. Biochem., Section 7, Abstract 7.42.
The Merck Manual, 5th edition, p. 671, 1987.

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