Treatment of protein malnourished bacterially infected humans wi

Details Treatment of protein malnourished bacterially infected humans wi Treatment of protein malnourished bacterially infected humans wi

1982-12-09

1985-09-17

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424 88, A61K 3514

Patent

active

045420173

ABSTRACT:
Exogenous LEM (Leukocyte Endogenous Mediator, also referred to as endogenous pyrogen) is parenterally administered to humans who are protein malnourished and are infected with bacteria, in order to preinitiate and then maintain the normal metabolic responses to the tissue damage occurring during infection, and thereby promote the normal metabolic response by the human.

REFERENCES:
Dinarello et al.--Chem. Abst., vol. 95 (1981), p. 113,212a.
Chem. Abst., General Subject Index, 10th Collective, vol. 86-95 (1977-1981), p. 13929GS.
L. Hoffman-Goetz and M. J. Kluger, "Protein Deprivation: Its Effects on Fever and Plasma Iron During Bacterial Infection in Rabbits," J. Physiol., 295, (1979), pp. 419-430.
L. Hoffman-Goetz and M. J. Kluger, "Protein Deficiency: Its Effects on Body Temperature in Health and Disease States," Am. J. Clin. Nutrition, 32, (Jul. 1979), pp. 1423-1427.
L. Hoffman-Goetz, et al., "Febrile and Plasma Iron Response of Rabbits Injected with Endogenous Pyrogen from Malnourished Patients," Am. J. Clin. Nutr., 34, (Jun. 1981), pp. 1109-1116.
R. A. Keenan, et al., "An Altered Response by Peripheral Leukocytes to Synthesize or Release Leukocyte Endogenous Mediator in Critically Ill, Protein-Malnourished Patients," J. Lab. and Clin. Med., 100, (Dec. 1982), pp. 844-857.
K. B. Harvey, et al., "Biological Measures for the Formulation of a Hospital Prognostic Index," Am. J. Clin. Nutr., 34, (Oct. 1981), pp. 2013-2022.
R. F. Kampschmidt and L. A. Pulliam, "Stimulation of Antimicrobial Activity in the Rat with Leukocytic Endogenous Mediator," J. Reticuloendothelial Soc., 17, (Mar. 1975), pp. 162-169.
M. C. Powanda and W. R. Beisel, "Hypothesis: Leukocyte Endogenous Mediator/Endogenous Pyrogen/Lymphocyte-Activating Factor Modulates the Development of Nonspecific and Specific Immunity and Affects Nutritional Status," Am. J. Clin. Nutr., 35, (Apr. 1982), pp. 762-768.
G. H. A. Clowes, Jr., et al., "Muscle Proteolysis Induced by a Circulating Peptide in Patients with Sepsis or Trauma," N.E. J. Med., 308, (Mar. 10, 1983), pp. 545-552.
V. Baracos, et al., "Stimulation of Muscle Protein Degradation and Prostaglandin E.sub.2 Release by Leukocyte Pyrogen (Interleukin-1)," N.E. J. Med., 308, (Mar. 10, 1983), pp. 553-558.
W. R. Beisel, "Mediators of Fever and Muscle Proteolysis," N.E. J. Med., 308, (Mar. 10, 1983), pp. 586-587.

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