Treatment of proliferative disorders, metastasaes, and drug resi

Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Heavy metal or compound thereof

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514492, A61K 3324, A61K 3128

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active

058434810

ABSTRACT:
The present invention relates to the use of vanadate compounds, or analogues of vanadate compounds, as antiproliferative and anti-metastatic agents, and to compositions containing vanadate compounds adapted for such use in methods for the treatment of proliferative disorders, methods of reducing the ability of a tumor to metastasize and methods for treating drug resistant tumors.

REFERENCES:
patent: 4882171 (1989-11-01), Posner et al.
patent: 5001141 (1991-03-01), Kerr et al.
patent: 5009891 (1991-04-01), Niwa et al.
patent: 5023358 (1991-06-01), Lazaro et al.
patent: 5036096 (1991-07-01), Suto
patent: 5045316 (1991-09-01), Kaplan
patent: 5069913 (1991-12-01), Posner et al.
patent: 5073639 (1991-12-01), Suto
patent: 5175001 (1992-12-01), Lazaro et al.
patent: 5527790 (1996-06-01), McNeill
patent: 5545661 (1996-08-01), Cullinan
patent: 5565491 (1996-10-01), Schieven
patent: 5583242 (1996-12-01), Schieven
Sardar, S.A., et al., Biol. Abstr. 95(10)AB-802, 110965, 1995.
Sakurai, H. 2nd Internat. Meeting on Molecular Mechanisms of Metal Toxicity, Jan. 10-17, 1993.
Dessureault, J. and Weber, J. Cell Biochem. 43:293-296, 1990.
Klarlund, J. et al., Biochim. Biophys. Acta. 971 112-120, 1988.
Keiler, J. et al., Acta Chirurgica Scandinavica-Supplementum, 343:154-64, 1965.
Stern et al., Biochem. Cell. Biol., 71:103, 1993.
William Lau, C.H. et al, Endocrinology, 123:2858, 1988.
Marchisio, P.C. et al., J. Cell. Biol. 37:151, 1988.
Wang and Scott, J. Cell, Physiol. 158:408-416, 1994.
Xuefeng Yin, et al., Molecular and Cellular Biochemistry 115:85-96, 1992.
Conquer, J.A. et al., 39th Annual Meeting, Orthopaedic Research Society, Feb. 15-18, 1993, San Francisco, CA.
Cruz, T. et al., Molecular and Cellular Biochemistry 153:161-166, 1995.
Conquer, J., et al., Annals N.Y. Acad. Sci. Sep. 1994, p. 447.
Wang and Scott, Mol. Cell. Biol. 153:59-67, 1995.
Younes, M. et al., Toxicology 66(1):63-74, 1991.
Sardar, S. et al., Tumor Research 28:51-61, 1993.
Younes, M. et al., Toxicology 7:141-149, 1991.
Sakurai, H. et al., Biochem Biophys Res Commun, 189(2):1090-1095, 1992.
Hanauske, U. et al., Int J Cell Cloning, 5(2):170-178, 1987.
Thompson, H.J. et al., Carcinogenesis, 5(6):849-851, 1984.
Bishayee, A. et al., Acta Physiol. Pharmacol. Bulg, 19/3:83-89, 1993.
A. Petkau, Br. J. Cancer, 55:87-95, 1987.
C. Norman Coleman, Seminars in Oncology 16:169-175, 1989.
Alvarez et al., J. Natl. Cancer Inst. 82(7):589-595, 1990.
Schultz et al., Cancer Res. 48, 5539-5545, 1988.
Wang & Stearns, Cancer Res. 48, 6262-6271, 1988.
Saxena et al., Biochem. Pharmacology 45(3): 539-542, 1993.
Shklar et al., Nutrition and Cancer, 20(2):145-151, 1993.
Kandel et al., Biochim. Biophys. Acta. 1053, 130-134, 1990.
Conquer, Biochim. Biophys. Acta. 1134, 1-6, 1992.
Cruz et al., Biochem. J. 277:327-330, 1991.
Slaga and Bracken, Cancer Research 37:1631-1635, 1977.
Clark, Pathology 18:181-186, 1986.
Schor, Biochem. Pharm. 37(9):1751-1761, 1988.
Fridovich, "Superoxide Dismutase in Biology and Medicine" in Pathology of Oxygen, American Press, Inc., Chapter 1, pp. 1-19, 1982.
Marklund et al., "Oxy-Radicals in the Toxicity of Cellular Toxins" in Oxy Radicals and Their Scavenger Systems, vol. II: Cellular and Medical Aspects, by Elsevier Science Publishing Co., Inc., pp. 96-104, 1983.
Machlin and Bendich, FASEB, 1:441-445, 1987.
Southorn and Powis, Mayo Clin. Proc. 63:381-388, 1988.
McLennan et al., Radiation Research, 84:122-132, 1980.
Scott et al., J. Biol. Chem., 264(5):2498-2501, 1989.
Edsmyr, Pathology of Oxygen, Superoxide Dismutase Efficacy in Ameliorating Side Effects of Radiation Therapy: Double-Blind, Placebo-Controlled Trials in Patients with Bladder and Prostate Tumors, in Chapter 19, pp. 315-326, Academic Press, Inc. 1982.
Thompson et al., Carcinogenesis, vol. 5, No. 6, pp. 849-851, 1984.
Hamada et al., Cancer Research, 48(17), 4926-32, 1988.
Ishikaiva et al., J. Biol. Chem. 268(27), 20116-25, 1993.

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