Treatment of plasmodium

Details Treatment of plasmodium Treatment of plasmodium

1997-05-09

1999-01-26

Gitomer, Ralph

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving luciferase

435 34, 435184, 5142378, C12Q 100, C12N 999

Patent

active

058637168

ABSTRACT:
Plasmodium is shown to have an inhibition sensitive sphingomyelin synthase activity necessary for ring and early trophozoite maturation. Inhibitors can therefore be used to treat malarial infection which can differentiate between inhibition sensitive Plasmodium sphingomyelin synthase and mammalian synthase. Inhibitors of interest include 1-phenyl-3-morpholino-2-acylated-aminopropanol-1.

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Haldar, K., "The Accumulation and Metabolism, "Mol. & Biochem Parasit (1991) vol. 49:143-156.
Vunnam, R., "Analogs of Ceramide That Inhibit, "Chem. & Physics of Lipids (1980) vol.26:265-278.

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