Drug – bio-affecting and body treating compositions – Dentifrices
Patent
1992-08-05
1993-08-31
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
424642, A61K 716, A61K 3330
Patent
active
052406962
ABSTRACT:
The present invention relates to the prevention of periodontitis by the use of a medicament which contains Triclosan. It has been found that Triclosan has a considerable anti-cyclo-oxygenase activity, thus inhibiting the formation of prostaglandins which are mediators of the loss of alveolar bone in the periodontium. Reducing the formation of said prostaglandins therefore reduces said loss of alveolar bone, which is one of the symptoms connected with periodontitis.
The medicament is preferably in the form of a toothpaste.
REFERENCES:
patent: 4287191 (1981-09-01), Coburn et al.
patent: 4358443 (1982-10-01), Coburn et al.
patent: 4522806 (1985-06-01), Muhlemann et al.
patent: 4575457 (1986-03-01), Mazarin
patent: 4664906 (1987-05-01), Sipos
patent: 4742083 (1988-05-01), Ritchey
patent: 4961924 (1990-10-01), Suhonen
patent: 4997640 (1991-03-01), Bird et al.
patent: 5015467 (1991-05-01), Smitherman
patent: 5094842 (1992-03-01), Riley
C.A. 117:239515T (1992), EP. 50852y Oct. 14, 1992, Hughes et al.
Agents and Actions, vol. 29, No. 3/4 (1990), pp. 232-238 "Inhibition of human perodontal prostaglandin E.sub.2 synthesis with selected agents".
J. Clin Periodontal, vol. 18, No. 6, Jul. 1991, pp. 462-467 and 468-473 and vol. 17, No. 8, 1990, pp. 570-574.
The Merck Manual, pp. 2104-2106 1987.
Colgate Brochure entitled, "PerioGard: Setting New Standards in Periodontal Care", specifically the page entitled: Colgate Gum Protection Formula Toothpaste, 1985.
Cummins Diane
Hull Derek M.
Van Der Ouderaa Franciscus J.
Chesebrough-Pond's USA Co. Division of Conopco, Inc.
Honig Milton L.
Rose Shep K.
LandOfFree
Treatment of periodontitis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatment of periodontitis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of periodontitis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2296003