Treatment of patients infected with hepatitis B virus with a hum

Details Treatment of patients infected with hepatitis B virus with a hum Treatment of patients infected with hepatitis B virus with a hum

1995-06-06

1997-07-15

Feisee, Lila

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241421, 4241611, 4241331, A61K 3942, A61K 39395

Patent

active

056480776

ABSTRACT:
Monoclonal antibodies effective for the diagnosis and treatment of hepatitis B have been prepared from a cell line obtained by fusing a xenogeneic hybridoma designated SPAZ 4 with blood cells of a patient immunized with hepatitis B vaccine. The chimeric human monoclonal antibody, PE1-1, (ATCC HB 9234), is used in a method of treating patients infected with hepatitis B virus.

REFERENCES:
patent: 4883752 (1989-11-01), Eda et al.
Samuel et al (1991) Lancet 337:813-815.
Matsui et al, Nichi Dai I Shi 41:1163-71, 1982.
Matsui et al (1982) Nichidai Igaku Zasski 41(12):1163-1171.
Ogata et al (1993) Proc. Nat'l Acad Sci. 90:3014-3018.
Neurath et al (1986) Vaccine 4:35-37.
Stricker et al (1985) Scavd. J. Immunol. 22:337-343.
Ichimon et al (1985) Biochem. Biophys. Res. Commun. 129(1):26-33.

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