Treatment of Parkinson's disease with (+)2-(ethyl-2,3-dihydroben

Details Treatment of Parkinson's disease with (+)2-(ethyl-2,3-dihydroben Treatment of Parkinson's disease with (+)2-(ethyl-2,3-dihydroben

1997-03-26

1999-09-07

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31415

Patent

active

059488069

ABSTRACT:
The present invention relates to the use of efaroxan and its derivatives for the preparation of a medicinal product intended for the treatment of Parkinson's disease.

REFERENCES:
patent: 5173502 (1992-12-01), Malen et al.
patent: 5281607 (1994-01-01), Stone et al.
Joly et al., Arch. Int. Pharmacodyn. Ther. 277(2) pp. 180-191, 1985.
Chapleo et al., J. Med. Chem. 27(5), pp. 570-576, 1984.
Ghika et al., Neurology 41(7), pp. 986-991, 1991.
Mavridis et al., Brain Res. 562(2) pp. 216-224, 1991.
Craig et al. "Modern Pharmacology", p. 16, 1982.
Christopher Chapleo, et al., .alpha.-Adrenoreceptor Reagents. 2. Effects of Modification of the 1,4-Benzodioxan Ring System on .alpha.-Adrenoreceptor Activity, J. Med. Chem. 27, 570-576 (1984).
Michael Stillings, Christopher Chapleo, et al., .alpha.-Adrenoreceptor Reagents. 3. Synthesis of Some 2-Substituted 1,4-Benzodioxans as Selective Presynaptic .alpha..sub.2 -Adrenoreceptor Antagonists, J. Med. Chem. 28, 1054-1062 (1985).
Costall B. and Naylor R.J. A comparison of circling models for the detection of antiparkinson activity. Psychopharmacologia 41, 57-64, 1975.
Silverman P.B. On-off effects of dopamine receptor agonists in the hemi-parkinsonian rat. Eur. J. Pharmacol. 242, 31-36, 1993.
Ungerstedt U. Post-synaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigrostriatal dopamine system. Acta Physiol. Scand. 367, 69-93, 1971.

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