Treatment of PAF and histamine-mediated diseases with 8-chloro-1

Details Treatment of PAF and histamine-mediated diseases with 8-chloro-1 Treatment of PAF and histamine-mediated diseases with 8-chloro-1

1995-02-21

1995-12-19

Wu, Shean

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 93, A61K 31435, C07D40102

Patent

active

054768560

ABSTRACT:
The present invention relates to 8-chloro-11-[1-[(5-methyl-3-pyridyl)methyl]-4-piperidyliden]-6,11-dihydro- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine, to a process for its preparation and to pharmaceutical compositions containing it. This compound is a dual PAF antagonist and antihistamine.

REFERENCES:
patent: 4282233 (1981-08-01), Vilani
patent: 4826853 (1989-05-01), Piwinski et al.
patent: 5089496 (1992-02-01), Piwinski et al.
patent: 5151423 (1992-09-01), Piwinski et al.
patent: B5151423 (1994-08-01), Piwinski et al.
patent: 5358953 (1994-10-01), Alker et al.
patent: 5360907 (1994-11-01), Lentz et al.
Wichterman, K. et al., Journal of Surgical Research, vol. 29, 189-201 (1980).
Terashita, Z. et al., European Journal of Pharmacology, vol. 109, 257-261 (1985).
Lefer, A., "Significance of Lipid Mediators in Shock States", Circulatory Shock, vol. 27, 3-12 (1989).
Herbert, J. et al., European Journal of Pharmacology, vol. 205, 271-276 (1991).
Schumacher et al., J. Org. Chem., 1989, 54, 2242-2244.
Bruneau et al., J. Med. Chem., 1991, 34, 1028-1036.
Rebek et al., J. Am. Chem. Soc., 1985, 107, 7487-7493.
Born, Proceedings of the Physiological Society, Mar. 1962, vol. 23-24, 67 p.
Young et al., Prostaglandins, 1985, 30, 545-551.

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