Treatment of osteoporosis and autoimmune disease with...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

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C514S182000

Reexamination Certificate

active

07345035

ABSTRACT:
The invention provides methods of downregulating mRNA encoding osteopontin comprising administering to a cell or mammal an amount of astrogorgiadiol effective to downregulate production of mRNA encoding osteopontin. The invention also provides methods of treating osteoporosis and autoimmune disease comprising administering to a patient in need of such treatment a therapeutically effective amount of astrogorgiadiol. Pharmaceutical compositions comprising astrogorgiadiol and a pharmaceutically acceptable carrier or diluent are also provided.

REFERENCES:
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Merck Index, 10thed., 1983, monograph 212, pp. 34-35.
Taber, D.F. et al., J. Org. Chem. 2001, 66, 944-953; “Synthesis of (-)-Astrogorgiadiol”.
Taber, D.F. et al., J. Org. Chem. Jul. 12, 2002, 67, 4821-4827; “Synthesis of (-)-Calicoferol B” (published on Web Jun. 13, 2002).
Farach-Carson, M.C. et al., American Physiological Society,1993, 265, F705-F711; “22-Osacalcitrol: dissection of 1,25(OH)2D3receptor-mediated and Ca2+entry-stimulating pathways”.
Fusetani et al., Tetrahedron Letters 1989, 30, 7079-7082, “Astrogorgiadiol and astrogorgin, inhibitors of cell division in fertilized starfish eggs, from a gorgonian”, (Abstract).
Chabas D. et al., Science 2001, 294, 1731-1735, “The Influence of the Proinflammatory Cytokine, Osteopontin, on Autoimmune Demyelinating Disease”.
Forton, et al., Human Mutation 2002, Mutation in Brief #496 Online, “An Osteopontin (SPP1) Polymorphism is Associated with Systemic Lupus Erythematosus”.
Yoshitake, H. et al., Proc. Nat'l Acad. Sci. USA 1999, 96, 8156-8160, “Osteopontin-deficient mice are resistant to ovariectomy-induced bone resporption”.

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