Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2003-10-15
2010-02-09
Tsang, Cecilia (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
07659246
ABSTRACT:
This invention relates to methods of treatment of osteoarthritis, and especially to treatment of this condition with cyclic peptidic and peptidomimetic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists of the C5a receptor, and are active against C5a receptors on polymorphonuclear leukocytes and macrophages. Particularly preferred compounds for use in the invention are disclosed.
REFERENCES:
patent: 7410945 (2008-08-01), Woodruff et al.
patent: WO 99/00406 (1999-01-01), None
Finch A. M. et al., “Low-Molecular-Weight Peptidic and Cyclic Antagonists of the Receptor for the Complement Factor C5a”, 1999, J. Med. Chem. vol. 42:1965-1974.
Woodruff et al. “Antiarthritic Activity of an Orally Active C5a Receptor Antagonist Against Antigen-Induced Monarticular Arthritis in the Rat”, Sep. 27, 2002, Arthritis & Rheumatism, vol. 46. pp. 2476-2485.
Strachan et al. “A New Small Molecule C5a Receptor Antagonist Inhibits the Reverse-Passive Arthus Reaction and Endotoxic Shock in Rats”, 2000, The Journal of Immunology, vol. 164. pp. 6560-6565.
Kivitz et al. “Randomized placebo-controlled trial comparing efficacy and safety of valdecoxib with naproxen in patients with osteoarthritis” J. Fam. Prac., 2002, 51, 530-7.
Fairlie David
Shiels Ian Alexander
Bradley Christina
Haynes and Boone LLP
Moore Mark D.
Promics Pty Limited
Tsang Cecilia
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