Treatment of ophthalmic infections using antimicrobial peptides

Details Treatment of ophthalmic infections using antimicrobial peptides Treatment of ophthalmic infections using antimicrobial peptides

2007-07-17

2007-07-17

Chism, B. Dell (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S018700, C514S016700, C514S002600

Reexamination Certificate

active

10442683

ABSTRACT:
The present invention discloses a method of treating an ophthalmic infection by administering to a vertebrate inflicted with the ophthalmic infection an ophthalmologically effective amount of an antimicrobial peptide which is derived from alpha-melanocyte-stimulating hormone (α-MSH) and biologically functional equivalents thereof. Specifically, the antimicrobial peptides derived from alpha-melanocyte-stimulating hormone (α-MSH) include α-MSH (1–13) which is SYSMEHFRWGKPV, α-MSH (4–10) which is MEHFRWG, α-MSH (6–13) which is HFRWGKPV, α-MSH (11–13) which is KPV, and a KPV dimer. The ophthalmic infection can be caused by a microorganism which include a bacteria, a fungi or a virus. The vertebrate includes a bird and a mammal. The antimicrobial peptide has anti-bacterial, antifungal, and antiviral property and therefore can be administered at the onset of the ophthalmic infection before the microorganism causing the infection is determined as well as thereafter.

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