Treatment of ocular hypertension with class I calcium channel bl

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

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514913, A61K 31275

Patent

active

049818716

ABSTRACT:
Elevated intraocular pressure in a mammalian eye is lowered by administering to the eye an amount of a Class I calcium channel blocking agent effective to lower the elevated intraocular pressure. A preferred calcium channel blocking agent is verapamil and the preferred mode of administration is topical directly to the eye, e.g., with drops.

REFERENCES:
patent: 4612329 (1986-09-01), Itoh et al.
patent: 4686217 (1987-08-01), Baxter et al.
Chem. Abst., 86:183,208s (1977)-Green et al.
"Elevation of Intraocular Pressure by Calcium Channel Blockers", Jean F. Beatty, M.D., et al, Arch Ophthalmol, vol. 102, Jul. 1984, pp. 1072-1076.
"Anaesthetic Implications of Calcium Channel Blockers", Leonard C. Jenkins et al, Can Anaesth. Soc. J. 1985, 32:4, pp. 436-447.
"The Effect of a Calcium-Channel Blocking Agent on Intraocular Pressure", Monica L. Monica, M.D. et al, American Journal of Ophthalmology, Dec. 1983, p. 814.

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