Treatment of non-HIV neuropathic pain syndromes

Details Treatment of non-HIV neuropathic pain syndromes Treatment of non-HIV neuropathic pain syndromes

Filed on

1995-02-08

Date issued

1996-07-09

Examiner

Scheiner, Toni R.

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Peptide containing doai

Other Related Categories

514 17, A61K 3800

Type

Patent

Status

active

Patent number

055344950

Description

ABSTRACT:
The present invention relates to methods of treating diabetic and other non-HIV related neuropathic pain. The methods involve administration of an effective amount of defined linear peptides to patients. The peptides can be administered for example, as a powder or a solution obtained by dissolving a powder in a pharmaceutically acceptable solvent. Intranasal or sublingual administration of the defined peptides is the most preferred treatment.

REFERENCES:
patent: 3531258 (1970-09-01), Merrifield et al.
patent: 5063206 (1991-11-01), Bridge et al.
patent: 5446026 (1995-08-01), Ruff et al.
Cecil Textbook of Medicine, 19th Edition, p. 2117-2124 and 2230-2236.
Neuropathic Pain Syndromes, Mitchell B. Max, Advances in Pain Research and Therapy, vol. 18, Raven Press, Ltd. New York 1991; pp. 193-219.
Peptide T Sequences Prevent Neuronal Cell Death Produced by the Envelope Protein (gp120) of the Human Immunodeficiency Virus, D. E. Brenneman, et al, Drug Development Research 15: 361-369 (1988).
Role of Peptide T in Palliation of HIV-1 Related Painful Peripheral Neuropathy, D. K. MacFadden, VII Internatl. Conference on AIDS, Florence 191, W.B. 2173.
HIV Envelope Protein-Induced Neuronal Damage and Retardation of Behavioral Development in Rat Neonates, Hill et al, Brain Research, 603 (1993) 222-23.
Society For Neuroscience Abstract, GP-120 Administered Intrathecally Induces Monoparesis in Rats, J. L. Steinman, et al, May 3, 1993.

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