Treatment of neuropathic pain with zinc finger proteins

Details Treatment of neuropathic pain with zinc finger proteins Treatment of neuropathic pain with zinc finger proteins

2007-08-07

2007-08-07

Wehbe′, Anne M. (Department: 1632)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

Reexamination Certificate

active

11096706

ABSTRACT:
A variety of zinc finger proteins (ZFPs) and methods utilizing such proteins are provided for use in treating neuropathic pain. ZFPs that bind to a target site in genes that are aberrantly expressed in subjects having neuropathic pain are described. In addition, ZFPs that bind to a target site in genes expressed at normal levels in subjects experiencing neuropathic pain, modulation of whose expression results in decreased pain perception, are also provided. For example, genes that are over-expressed in the dorsal root ganglia (DRG) of pain patients (e.g., VR1, TRKA and/or Nav1.8) can be repressed, whereas genes that are under-expressed in the same populations can be activated.

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Jouvenot et al., “Gene Control as a Therapeutic Intervention: Zinc-Finger Protein Transcription Factors as Regulators of the Molecular Determinants of Neuropathic Pain,”Molecular Therapy,9(suppl. 1):S90, # 233 (2004).
Tan et al., “Zinc Finger Protein Transcription Factors as Potential Therapeutic Agents for the Treatment of Neuropathic Pain,”Molecular Therapy,11(suppl. 1):S250, # 646 (2005).

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