Treatment of neuropathic pain with 6 H -pyrrolo[3,4- d...

Details Treatment of neuropathic pain with 6 H -pyrrolo[3,4- d... Treatment of neuropathic pain with 6 H -pyrrolo[3,4- d...

2003-07-08

2008-12-16

Jiang, Shaojia Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S236000

Reexamination Certificate

active

07465730

ABSTRACT:
6H-pyrrolo[3,4-d]pyridazine compounds and methods of their use of as ligands of voltage gated calcium channels (VGCC), useful in the treatment of neuropathic pain, and psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, panic, and bipolar disorder, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm disorders, drug addiction, drug abuse, drug withdrawal and other.

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The Merck Manual of Diagnosis and Therapy, Seventeenth Edition, published 1999 by Merck Research Laboratories, edited by Beers and Berkow, pp. 1371-1372.
Merriam-Webster's Collegiate Dictionary, Tenth Edition, published by Merriam-Webster Incorporated, p. 924.
Uchida et al., “Synthetic Approaches to Fused Heteroaromatic Compounds by the Condensation Reactions of Functional Pyrroles (1)” Journal of Heterocyclic Chemistry (1978) vol. 15, pp. 241-248.
Rips et al., “Friedel-Crafts Acylations of 1-Phenyl-2,5-dimethylpyrrole and 1,2-Diphenyl-5-methylpyrrole”, Journal of Organic Chemistry, 1959, 24, pp. 551-554.

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