Treatment of neurological dysfunction with methylcobalamin

Details Treatment of neurological dysfunction with methylcobalamin Treatment of neurological dysfunction with methylcobalamin

1993-07-07

1996-04-16

Kunz, Gary L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514561, 536 2644, 562559, A61K 3170, A61K 3324, A61K 3140, C07H 1923

Patent

active

055082718

ABSTRACT:
A method for treating neurological dysfunctions associated with AIDS or ARC comprising the administration of methylcobalamin, alone or in combination with methionine. Substantial increases in the number of T4+ T-lymphocytes, T8+ T-lymphocytes, or the ratio of T4+ to T8+ T-lymphocytes is also observed with this treatment.

REFERENCES:
patent: 5137712 (1992-08-01), Kask et al.
Kieburtz et al., "Abnormal Vitamin B.sub.12 Metabolism in Human Immunodeficiency Virus Infection", Arch. Neurol., 48:312-314 (1991).
Pfohl et al., "Effect of Cobalamin Derivatives on in Vitro Enzymatic DNA Methylation: Methylcobalamin Can Act as a Methyl Donor", Biochemistry, 30(32):8045-8051 (1991).
Sakane et al., "Effects of Methyl-B.sub.12 on the in Vitro Immune Functions of Human T Lymphocytes", J. of Clin. Immunology, 2(2):101-109 (1982).
Scott and Weir, "Hypothesis: The Methyl Folate Trap", The Lancet, Aug. 15, pp. 337-340 (1981).
Surtees et al., "Association of Demyelination with Deficiency of Cerebrospinal-fluid S-adenosylmethionine in Inborn Errors of Methyl-transfer Pathway", The Lancet, 338:1550-1554 (1991).
Surtees et al., "Central-nervous-system Methyl-group Metabolism in Children with Neurological Complications of HIV Infection", The Lancet, 335:619-621 (1990).
Yaqub et al., "Effects of Methylcobalamin on Diabetic Neuropathy", Clinical Neurology and Neurosurgery, 94:105-111 (1992).

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