Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2006-06-13
2006-06-13
Crouch, Deborah (Department: 1632)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S320100, C435S325000
Reexamination Certificate
active
07060429
ABSTRACT:
This invention relates to a method of treating or preventing neuro-degenerative disorders and neuro-developmental disorders by altering the ratio of the amount of full-length TrkB polypeptide to the amount of truncated TrkB polypeptides in a neuron or by altering the ratio of the amount of full-length TrkC polypeptide to the amount of truncated TrkC polypeptides in a neuron.
REFERENCES:
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Somia N, Gene therapy: trials and tribulaions, 2000, Nature Reviews Genetics 1, 91-99.
Kennedy PGE, Potential use of herpes simplex virus (HSV) vectors for gene therapy of neurological disorders, 1997, Brain, 120, 1245-1259.
Klau M, Reduced number of functional glutamatergic synapses in hippocampal neurons overexpressing full-length TrkB receptors, 2001, J. of Neuroscience Research, 66, 327-336.
Bambrick LL, Glutamate as a hippocampal neuron survival factor: An inherited defect in the trisomy 16 mouse, 1995, PNAS, vol. 92, pp. 9692-9696.
Notification of Transmittal of International Preliminary Examination Report issued in corresponding PCT US/02/0515.
Bambrick Linda L.
Dorsey Susan G.
Kingsbury Tami J.
Krueger Bruce K.
Buchanan & Ingersoll PC
Crouch Deborah
Montanari David A.
University of Maryland Baltimore
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