Treatment of neurodegenerative conditions with nimesulide

Details Treatment of neurodegenerative conditions with nimesulide Treatment of neurodegenerative conditions with nimesulide

1997-04-01

1999-11-16

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

A61K 3116

Patent

active

059859300

ABSTRACT:
The present invention relates to the use of nimesulide and structurally related compounds in the prevention and/or treatment of neurodegenerative conditions. It is based, at least in part, on the discovery that nimesulide exhibits a neuroprotective effect against .beta.-amyloid induced cell death. Without being bound to any particular theory, it appears that nimesulide inhibits a non-inflammatory mechanism of neurodegeneration.

REFERENCES:
patent: 5486534 (1996-01-01), Lee et al.
patent: 5510361 (1996-04-01), Scherz et al.
patent: 5510368 (1996-04-01), Lau et al.
patent: 5545656 (1996-08-01), Loose et al.
patent: 5547975 (1996-08-01), Talley et al.
patent: 5604260 (1997-02-01), Guay et al.
Graham et al., 1996, Soc. for Neuroscience 22:Abstr. 818.15.
Tsujii and DuBois, 1995, Cell 83:493-501.
Lundberg et al., 1997, Nature Med 3:30-31.
Crowe et al., 1997, Nature Med. 3:73-76.
Adams et al., 1996, J. Neurochem. 66:6-13.
Aisen et al., 1996, Dementia 7:201-206.
Anderson et al., 1996, The Journal of Neuroscience 16(5):17170-1719.
Chang et al., 1996, Neurobiology of Aging (17)5:801-808.
Li et al., 1996, Brain Research 738:196-204.
McGreer et al., 1996, Neurology 47:425-432.
Nakayama et al., 1996, Society for Neuroscience 22:1670.
Kaufman et al., 1996, Proc. Natl. Acad. U.S.A. 93:2317.
Pasinetti et al., 1996, Neurobiology of Aging 17(5):707-716.
Paul S. Aisen, 1995, Dementia 9(2):173-182.
Anderson et al., 1995, Journal of Neurochemistry 65(4):1487-1498.
Oda et al., 1995, Alzheimer's Research 1:29-34.
Aisen and Davis, 1994, Am J. Psychiatry 151(8):1105-1113.
Anderson et al., 1994, Experimental Neurology 125:286-295.
Loo et al., 1993, Proc. natl. Acad. Sci. USA 90:1-5.
Rogers et al., 1993, Neurology 43: 1609-1611.
Yamagata, 1993, Neuron 11:371-386.
Merck Index, p. 1125, No. 6640 Nimesulide.
IBC's Industry Symposium on COS-2 Inhibitors, Aug. 6-7, 1998, San Diego, CA, abstract by Dr. Pasinetti.
Mattson, 1998, Science & Medicine Mar./Apr.:16-25.
McGeer and McGeer, 1998, Neurol. Rev.1(Suppl.):8-11.
Needleman and Isakson, 1998, Science & Medicine Jan./Feb.:26-35.
Lukiw and Bazan, 1997, Soc. for Neurosci. Abstracts 23:2171.
Lukiw and Bazan, 1997, J. Neurosci. Res. 50:937-945.
Fagarasan and Aisen, 1996, Brain Res. 723:231-234.
Nakayama et al., 1996, Soc. for Neurosci. Abstracts 22:1670.
Rabasseda, 1996, Drugs of Today 32:365-384.
Tocco et al., 1996, Soc. for Neurosci. Abstracts 22:215.
Yang et al., 1996, J. Am. Soc. Nephrol. 7:1652. (Abstract only).
Nakayama et al., 1995, Soc. for Neurosci. Abstracts 21:1268.
Smale et al., 1995, Exp. Neurol. 133:225-230.
Zhu et al., 1995, Soc. for Neurosci. Abstracts 21:300.
Murphy et al., 1989, Neuron 2:1547-1558.

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