Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1975-02-12
1977-01-25
Rosen, Sam
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
A61K 31505
Patent
active
040052044
ABSTRACT:
Method and pharmaceutical preparations for treating meningeal leukemia, CNS Iymphoma and neoplasms in the brain which comprises treating an infected mammal such as a human with a dose of an effective treatment amount of a compound of Formula I ##STR1## where R is a straight or branched chain lower alkyl of 1 to 4 carbon atoms, and X is a halogen atom (fluorine, chlorine, bromine or iodine) and pharmaceutically acceptable salts thereof.
Preferred compounds for treatment of the aforementioned diseases are 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine and 2,4-diamino-5-(3',4'-dichlorophenyl)-6-ethylpyrimidine.
REFERENCES:
murphy et al. J. Clin. Invest. vol. 33 (1954) pp. 1388 et. seq.
Geils et al--Blood vol. 38 No. 2 (1971) pp. 131-137.
Elion Gertrude B.
Hitchings George H.
Nichol Charles A.
Simmons William S.
Stickney Dwight R.
Brown Donald
Burroughs Wellcome Co.
Rosen Sam
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