Treatment of myocardial failure

Details Treatment of myocardial failure Treatment of myocardial failure

1993-01-29

1994-09-27

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

514168, A61K 3159

Patent

active

053507452

ABSTRACT:
Method of increasing the strength of contraction in the mammalian heart muscle by administering to the mammal an effective amount of an activated Vitamin D compound, i.e. a 1.alpha.-hydroxylated Vitamin D compound which binds with the Vitamin D receptor and produces a positive inotropic effect in the heart muscle. The activated Vitamin D compound may be given as a means to treat myocardial failure.

REFERENCES:
patent: 4501737 (1985-02-01), Yamato et al.
M. R. Walters et al., 1,25-Dihydroxyvitamin D.sub.3 Receptors Identified in the Rat Hear. J. Mol. Cell. Cardiol. 1986; 18:67-72.
R. E. Weishaar and R. U. Simpson. Vitamin D.sub.3 and Cardiovascular Function in Rats. J. Clin. Invest. 1987; 79:1706-1712.
R. E. Weishaar and R. U. Simpson. Involvement of Vitamin D.sub.3 with Cardiovascular Function II. Direct and Indirect Effects. Am. J. Physiol. 1987; 253 (Endocrinol Metab 16):E675-E683.
J. Sellers and R. Boland. Rapid Stimulation of Calcium Uptake and Protein Phosphorylation in Isolated Cardiac Muscle by 1,25-dihydroxyvitamin D.sub.3. Mol. and Cell. Endocrinol. 1991; 77:67-73.
Weishaar et al., Chemical Abstracts, vol. 112 (15), No. 133090g, 1990.

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