Treatment of myeoproliferative diseases

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S155000

Reexamination Certificate

active

07842681

ABSTRACT:
Methods of reducing the number of platelets in mammals and preventing or treating pro-thrombotic conditions and diseases that are characterized by an excess of, or undesired activation of, platelets using inhibitors of anti-apoptotic Bcl-2 family protein members is disclosed.

REFERENCES:
patent: 5306709 (1994-04-01), Gewirtz
patent: 6703382 (2004-03-01), Wang et al.
patent: 6720338 (2004-04-01), Augeri et al.
patent: 7030115 (2006-04-01), Elmore et al.
patent: 7358251 (2008-04-01), Elmore et al.
patent: 7390799 (2008-06-01), Bruncko et al.
patent: 7449485 (2008-11-01), Elmore et al.
patent: 7504512 (2009-03-01), Augeri et al.
patent: 7585858 (2009-09-01), Elmore et al.
patent: 7642260 (2010-01-01), Bruncko et al.
patent: 2002/0086887 (2002-07-01), Augeri et al.
patent: 2003/0119894 (2003-06-01), Murthy et al.
patent: 2004/0209907 (2004-10-01), Franklin
patent: 2006/0128706 (2006-06-01), Bruncko et al.
patent: 2006/0258657 (2006-11-01), Bruncko et al.
patent: 2007/0015787 (2007-01-01), Bruncko et al.
patent: 2007/0027135 (2007-02-01), Bruncko et al.
patent: 2007/0072860 (2007-03-01), Bruncko et al.
patent: 2008/0287419 (2008-11-01), Bruncko et al.
patent: 230136 (1991-12-01), None
patent: WO 00/04901 (2000-02-01), None
patent: WO 02/13833 (2002-02-01), None
patent: WO 02/24636 (2002-03-01), None
patent: WO 02/098848 (2002-12-01), None
patent: WO 2005/049594 (2005-06-01), None
patent: WO 2007/040650 (2007-04-01), None
patent: WO 2008/017121 (2008-02-01), None
patent: WO 2008/017123 (2008-02-01), None
Hawkins et. al., Meyloproliferative Disorders, University of Maryland Medical Center, online publication, Oct. 19, 2006.
Oltersdorf., An inhibitor of Bcl-2 family proteins induces regression of solid tumours, Nature, vol. 435, May 15, 2005.
Zhang et. al. (Haematologica (2004) 89:1199-1206).
Gangat et. al. (Expert Opinion on Pharmacotherapy (2008) 9:1679-1685.
Lengfelder et. al. (Seminars in Thrombosis and Hemostasis (2006) 32:267-275).
Yanhong Ma et. al., Biochimmica et Biophysica Acta (2009) 1073-1079.
Finazzi, et al., “Essential Thrombocythemia”, Seminars in Hematology, 42, 230-238 (2005).
Harrison, et al., “Hydroxyurea Compared with Anagrelide in high-Risk Essential Thrombocythemia”, New Engl J Med, 353, 33-45 (2005).
IUPAC 1974 Recommendations for Sec E, Fundamental Stereochemistry, Pure Appl Chem,45,13-30 (1976).
Lengfelder, et al., “Diagnosis and Therapy of Polycythemia Vera”, Seminars In Thrombosis and Hemostasis, 32 (3), 267-275 (2006).
Mitra, et al., “In Stent restenosis: bane of the stent era”, J Clin Pathol, 59, 232-239 (2006).
Petros, et al., “Solution structure of the antiapoptotic protein bcl-2”, PNAS, 98(6), 3012-3017 (2001).
Sattler, et al., “Structure of Bcl-xL-Bak Peptide Complex: Recognition Between Regulators of Apoptosis”, Science 275, 983-986 (1997).
Weston, et al., “Antiplatelet Drugs in Cardiovascular Diseases”, International Journal of Clinical Practice, 57(10), 898-905 (2003).
Zhang, et al., “Development of a high-throughput fluorescence polarization assay for Bcl-xL”, Analytical Biochemistry, 307, 70-75 (2002).
Zhang, et al., “Bcl-2 family proteins are essential for platelet survival”, Cell death and Differentiation, 14, 943-951 (2007).
Mason, et al., “The Bcl-2 Protein Family Is Essential for Platelet Survival in Vivo”, Blood (48th ASH Annual Meeting Abstracts) vol. 108 No. 11, Part 1 pp. 209A (2006).
Merritt, et al., “The Efficacy and Safety of Perioperative Antiplatelet Therapy”, Journal of Thrombosis and Thrombolysis, 17(1), 21-27 (2004).
Letai, A., 2005, “The BCL-2 network: Mechanistic insights and therapeutic potential,”Drug Discovery Today: Disease Mechanisms, vol. 2(2):145-151.
Mitten, M.J. et al., 2005, “The Bcl-2 inhibitor ABT-737 shows significant anit-tumor efficacy in a model of non-Hodgkin's B cell lymphoma,”Proceedings of the Annual Meeting of the American Association for Cancer Research, vol. 46:399-400.
PCT International Written Opinion dated Jul. 29, 2008, in International Application No. PCT/US2007/077579, filed Sep. 5, 2007.
PCT International Search Report Jul. 29, 2008, in International Application No. PCT/US2007/077579, filed Sep. 5, 2007.
U.S.P.T.O. Non-Final Office Action dated Sep. 12, 2008, in U.S. Appl. No. 11/202,827, filed Aug. 12, 2005.
U.S.P.T.O. Non-Final Office Action dated Aug. 21, 2008, in U.S. Appl. No. 11/127,940, filed May 12, 2005.
Shimazaki, et al., “Evaluation of apoptosis as a prognostic factor in myelodysplastic syndromes”, British J Haematology, 110(3), 584-590 (2000).
Tse et al., “ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor,” May 1, 2008, Cancer Research 68(9):3421-3428.
U.S.P.T.O., Non-final Office Action dated Aug. 21, 2009 in U.S. Appl. No. 11/127,940.
Wagner et al., “Conditional deletion of theBcl-xgene from erythroid cells results in hemolytic anemia and profound splenomegaly,” Development, 127, 4949-4958 (2000).
Birgegard, et al., “Adverse effects and benefits of two years of anagrelide treatment for thrombocythemia in chronic myeloproliferative disorders,” Haematologica, 2004, 89, pp. 520-527.
Degterev, et al., “Identification of small-molecule inhibitors of interaction between the BH3 domain and Bel-xL,” Nature Cell Biology, 2001. 3, pp. 173-182.
Enyedy, et al., “Discovery of Small-Molecule Inhibitors of Bcl-2 through Structure-Based Computer Screening,” J. Med. Chem., 2001, 44, pp. 4313-4324.
James, et al., “A unique clonal JAK2 mutation leading to constituative signaling causes polycythaemia vera,” Nature, 2005, 434, pp. 1144-1148.
James, et al., “A JAK2 mutation in myeloproliferative disorders: pathogenesis and therapeutic and scientific prospects,” Trends in Molecular Medicine, 2005, 11, pp. 546-554.
Kutzki, et al., “Development of Potent Bcl-xl Antagonist Based on α-Helix Mimicry,” J. Am. Chem. Soc., 2002, 124, pp. 11838-11839.
Ma, et al., “Real-time bioluminescence imaging of polycythemia vera development in mice,” Biochemica et Biophysica Acta, 2009, 1792, pp. 1073-1079.
Pereira, et al., “Platelet aging in vivo is associated with activation of apoptotic pathways: studies in a model of suppressed thrombopoiesis in dogs,” Thromb. Haemost., 2002, 87(5), pp. 905-909.
P/S/L Consulting Group Inc., Press Release: “FDA Clears Agrylin for a Broader Patient Population,” Dec. 21, 1998, retrieved May 10, 2010, from Doctor's Guide: Global Edition website (http://www.pslgroup.com/dg/D57EE.htm).
Shire US Manufacturing Inc., Agrylin®—anagrelide hydrochloride capsule product label, 2005, pp. 1-8, downloaded May 16, 2010 from http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=14398#nlm34067-9.
Silva, et al., “Expression of Bcl-x in Erythroid Precursors from Patients with Polycythemia Vera,” The New England Journal of Medicine, 1998, 338, pp. 564-571.
The Leukemia & Lymphoma Society, “Polycythemia Vera,” Fact Sheet No. 13, p. 3, downloaded on May 18, 2010 from http://www.leukemia-lymphoma.org/attachments/National/br—1178803767.pdf.
Zeuner, et al., “Activity of the BH3 mimetic ABT-737 on polycythemia vera erythroid precursor cells,” Blood, 2009, 113, No. 7, pp. 1522-1525.

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