Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai
Patent
1994-06-23
1996-07-30
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C-o-group doai
514727, A61K 31045, A61K 3105
Patent
active
055412327
ABSTRACT:
A method and composition for treating multidrug resistance in a mammal, in which the composition includes NDGA or an analog of NDGA in accordance with the following formula: ##STR1## wherein R.sub.1 and R.sub.2 are independently H, lower alkyl or lower acyl;
REFERENCES:
patent: 4562298 (1985-12-01), Parkhurst et al.
patent: 4695590 (1987-09-01), Lippman
patent: 4708964 (1987-11-01), Allen
patent: 4774229 (1988-09-01), Jordan
patent: 4880637 (1989-11-01), Jordan
patent: 4954659 (1990-09-01), Parkhurst et al.
patent: 5008294 (1991-04-01), Jordan et al.
Sonneveld, et al., "Modulation of Multidrug-Resistant Multiple Myeloma by Cyclosporin", The Lancet, Aug. 1, 1992, vol. 340, No. 8814.
Carter, et al., "Chemotherapy of Cancer", Second Edition, A Wiley Medical Publication, 1981, pp. 361-365.
Author: Endicott, et al. Title: The Biochemistry of P-glycoprotein-Mediated Multidrug Resistance Publication: Ann. Rev. Biochem. (1989) 58, 137-171.
Author: Shalinsky, et al. Title: Regulation of Initial Vinblastine Influx by P-glycoprotein Publication: Br. J. Cancer, 67:30-36 (1993).
Author: Gottesman, et al. Title: The Multidrug Transporter, a Double-edged Sword Publication: J. Biol. Chem., 263(25):12163-6 (1966).
Author: Ford, et al. Title: Pharmacology of Drugs that Alter Multidrug Resistance in Cancer Publication: Pharmacol. Rev., 42(3):155-199 (1990).
Author: Murren, et al. Title: Why Haven't We Cured Multidrug Resistance Tumors?Publication: Oncol. Res., 4(1):1-6 (1992).
Author: Choi, et al. Title: An Altered Pattern of Cross-Resistance in Multidrug-Resistant Human Cells results from Spontaneous Mutations in the mdr1 (P-Glycoprotein) Gene Publication: Cell, 53:549-529 (1989).
Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, Eighth Edition (1990), McGraw Hill, Inc., New York, Section XII, pp. 1202-1263.
Cancer Principles and Practice of Oncology, 4th Ed., J. B. Lippincott Co., 1993, Table 18-1, 326-329.
Poster Presentation given at the national meeting of American Association for Cancer Research, at San Francisco, CA, Apr. 1994. The abstract of this poster has also been published in the Proceedings of American Association for Cancer Research, vol. 35, Abstract No. 2127.
Howell Stephen
Khandwala Atul
Sachdey Om P.
Smith Charles G.
Chemex Pharmaceuticals, Inc.
Criares Theodore J.
LandOfFree
Treatment of multidrug resistant diseases does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatment of multidrug resistant diseases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of multidrug resistant diseases will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1659112