Treatment of mood disorders with functional antagonists of the g

Details Treatment of mood disorders with functional antagonists of the g Treatment of mood disorders with functional antagonists of the g

1990-06-18

1992-02-04

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514557, A61K 31215, A61K 3119

Patent

active

050860720

ABSTRACT:
A method is disclosed for the treatment of mood disorders, including major depression, by administering an effective mood disorder treating amount of a compound possessing functional antagonist properties for the N-methyl-D-aspartate receptor complex.

REFERENCES:
Foster, A. C. et al., Nature, vol. 329, 395-396 (1987).
Kleckner et al, Science, vol. 241, 835-837 (1988).
Marvizon et al, J. Neurochem., vol. 52, 992-994 (1989).
Olney, J. B. Biol. Psychiatry, vol. 26, 505-525 (1989).
Skolnick et al, Life Sciences, vol. 45, 1647-1655 (1989).
Trullas et al, Europ. Journ. of Pharmac., vol. 185, 1-10 (1990).

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