Treatment of metastasis

Details Treatment of metastasis Treatment of metastasis

1986-01-21

1988-06-14

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514 46, 514218, 514258, 514264, 514307, 514455, 514573, A61K 3150, A61K 3170, A61K 3151, A61K 31505, A61K 3152, A61K 3147, A61K 3145, A61K 3119

Patent

active

047512245

ABSTRACT:
A method for reducing the incidence of metastasis in tumor victims without treating the primary tumor per se resides in the administration of forskolin or its analogs which are potent inhibitors of platelet aggregation. Forskolin compounds are generally defined as labdane diterpenoids having the general formula: ##STR1## These compounds may be administered alone or in combination with other inhibitors of platelet aggregation.

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patent: 4476140 (1984-10-01), Sears et al.
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Bhat et al., "Structures and Stereochemistry of New Labdane Diterpenoids from Coleus Forskohlii Briq..sup.1 ", Tetrahedron Letters, No. 19, pp. 1669-1672, 1977.
Adnot et al., "Forskolin (A Powerful Inhibit or of Human Platelet Aggregation)", Biochemical Pharmacology, vol. 31, No. 24, pp. 4074-4076, 1982.
Bhat et al., "The Antihypertensive and Positive Inotropic Diterpene Forskolin: Effects of Structural Modifications on its Activity", J. Med. Chem. 26, pp. 486-492, 1983.
de Souza et al., "Forskolin: A Labdane Diterpenoid With Antihypertensive, Positive Inotropic . . . ", Medicinal Research Reviews, vol. 3, No. 2, pp. 201-219 1983.
Agarwal & Parks, "Synergistic Inhibition of Platelet Aggregation by Forskoliln Plus . . . ", Biochemical Pharmacology, vol. 31, No. 22, pp. 3713-3716, 1982.
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