Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Derived from – or present in – food product
Reexamination Certificate
2001-11-15
2004-08-03
Leary, Louise N. (Department: 1651)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Derived from, or present in, food product
C424S130100, C424S535000
Reexamination Certificate
active
06770280
ABSTRACT:
BACKGROUND OF INVENTION
Many women suffer from menorrhagia, hypermenorrhea, dysmenorrhea, menstrual migraines and combinations thereof.
Menorrhagia is defined as excessive menstrual bleeding in the absence of organic pathology. Hypermenorrhea is defined as excessive duration of menstruation in the absence of organic pathology. Menorrhagia and hypermenorrhea have no known etiology. It has, however, been postulated that menorrhagia and hypermenorrhea are the result of an inappropriate exposure of the endometrium to hormones.
Menorrhagia is an exceedingly common problem, typically comprising approximately one in five outpatient referrals to gynecological departments. Women suffering severe menorrhagia are at risk for chronic anemia. Hypermenorrhea is also an exceedingly common problem.
Dysmenorrhea is a term used to describe painful menstruation. The pain may range from minor cramping to intense pain accompanied by diarrhea, nausea and vomiting, with sensations of pelvic heaviness and breast fullness.
Menstrual migraines is a term used to describe migraines which accompany menstruation.
Mankind has sought ways to treat menorrhagia, hypermenorrhea, dysmenorrhea and menstrual migraines, including efforts ranging from the consumption of specific foods to drug therapy such as treatment with oral contraceptives or progestin. While certain of these techniques have demonstrated limited success in decreasing the severity of menorrhagia, hypermenorrhea, dysmenorrhea and/or menstrual migraines, the search continues for drug-free alternatives.
SUMMARY OF INVENTION
I have discovered that menorrhagia, hypermenorrhea, dysmenorrhea and menstrual migraines can be treated by administering a therapeutic amount of an antibacterial milk product.
REFERENCES:
patent: 3282969 (1966-11-01), Boswell
patent: 4585651 (1986-04-01), Beck et al.
patent: 4636384 (1987-01-01), Stolle et al.
patent: 4732757 (1988-03-01), Stolle et al.
patent: 4732763 (1988-03-01), Beck et al.
patent: 4748018 (1988-05-01), Stolle et al.
patent: 4756907 (1988-07-01), Beck et al.
patent: 4879110 (1989-11-01), Beck et al.
patent: 4897265 (1990-01-01), Stolle et al.
patent: 4919929 (1990-04-01), Beck
patent: 4956349 (1990-09-01), Beck
patent: RE33403 (1990-10-01), Stolle et al.
patent: RE33565 (1991-04-01), Stolle et al.
patent: 5106618 (1992-04-01), Beck et al.
patent: 5128127 (1992-07-01), Beck
patent: 5194255 (1993-03-01), Beck et al.
patent: 5242691 (1993-09-01), Beck
patent: 5288496 (1994-02-01), Lewis
patent: 5352462 (1994-10-01), Beck
patent: 5367054 (1994-11-01), Lee
patent: 5401507 (1995-03-01), Lewis
patent: 5419910 (1995-05-01), Lewis
patent: 5427796 (1995-06-01), Lewis
patent: 5650175 (1997-07-01), Beck et al.
patent: 5814345 (1998-09-01), Beck et al.
patent: 5863561 (1999-01-01), Beck et al.
patent: 5980953 (1999-11-01), Beck et al.
patent: 6054124 (2000-04-01), Beck et al.
patent: 6056978 (2000-05-01), Beck et al.
patent: 0 127 712 (1989-01-01), None
patent: WO 92/00756 (1992-01-01), None
Filler, S. J., et al., “Effect of Immune Bovine Milk onStreptococcus mutansin Human Dental Plaque,” Archs Oral Biol 36:1, p. 41-47, 1991.
Gingerich, D.A., “Clinical and Pharmacologic Efficacy of Stolle Milk, Various Fractions, and WPI Plus,” Stolle Milk Biologics International, Efficacy of Stolle Milk Fractions, p. 2-25, 1997.
Golay, A., et al., “Cholesterol-Lowering Effect of Skim Milk from Immunized Cows in Hypercholesterolemic Patients,” Am J Clin Nutr, p. 1014-1019, 1990.
Davidson, et al., “Passive Immunisation of Children with Bovine Colostrum Containing Antibodies to Human Rotavirus,” The Lancet, p. 709-712, 1989.
Ebina, T., et al., “Prevention of Rotavirus Infection by Oral Administration of Cow Colostrum Containing Antihumanrotavirus Antibody,” Med Microbiol Immunol 174, p. 177-185, 1985.
Ebina, T., et al., “Treatment of Multiple Sclerosis with Anti-Measles Cow Colostrum,” Med Microbiol Immunol 173, p. 87-93, 1984.
“A Multicenter, Double-Blind, Placebo Controlled Study of Stolle Milk as Adjunct Therapy in Adult Rheumatoid Arthritis,” Stolle Milk Biologics International, Rheumatoid Arthritis.
Beck, L. R., et al., “Milk Lymphocyte Anti-Adhesion Factor, and its Role as an Anti-Microbial, Indigenous Antimicrobial Agents of Milk—Recent Developments,” Uppsala: International Dairy Federation, p. 62-72, 1993.
Berkow, R., The Merck Manual of Diagnosis and Therapy, p. 1792-93, 1805-07, 1992(16th Ed).
Hilpert, H., et al., “Use of Bovine Milk Concentrate Containing Antibody to Rotavirus to Treat Rotavirus Gastroenteritis in Infants,” J of Infect Dis 156:1, p. 158-166, 1987.
Ishida, A., et al., “Administration of Milk From Cows Immunized with Intestinal Bacteria Protects Mice from Radiation-Induced Lethality,” Biotherapy 5, p. 215-225, 1992.
Ishida, A. et al., “Consumption of Milk from Cows Immunized with Intestinal Bacteria Influences Age-Related Changes in Immune Competence in Mice,” J Nutr 122, p. 1875-1883, 1992.
Kobayashi, T., et al., “Protective Effect of Orally Administering Immune Milk on Endogenous Infection in X-Irradiated Mice,” Agric Biol Chem 55:9, p. 2265-2272, 1991.
Krick, G. et al., “Double Blind Controlled Trial on the Effect of Stolle Milk on Recovery After Excerise in Highly Trained Runners Protocal #RUN-1,” Stolle R&D, RUN-01, Stolle Milk in Runners Final Report, p. 1-14, 1993.
McClead, R., et al., “Orally Administered Bovine Colostral Anti-Cholera Toxin Antibodies: Results of Two Clinical Trails,” Am J of Med 85, p. 811-816, 1988.
Murosaki, S., et al., “Influence of Intake of Skim Milk from Cows Immunized with Intestinal Bacterial Antigens on Onset of Renal Disease in (NZB×NZW)F1Mice Fed Ad Libitum or Restricted in Energy Intake,” J. Nutr 121, p. 1860-1868, 1991.
Niedermeier, W., “Effects of Stolle Milk in Patients with Rheumatoid Arthritis: Double Blind, Placebo Controlled, Crossover Study,” Stolle Milk Biologics International, Immune Milk in Arthritis Dr. Niedermeier Clinical Trail Summary, p. 1-6.
Nomoto, K., et al., “Antibacterial Effect of Bovine Milk Antibody AgainstEscherichia coliin a Mouse Indigenous Infection Model,” Med Microbiol Immunol 181, p. 87-98, 1992.
Nord, J., et al., “Treatment with Bovine Hyperimmune Colostrum of Cryptosporidial Diarrhea in AIDS Patients,” AIDS 4, p. 581-584, 1990.
Ormond, D. et al., “A Low Molecular Weight Component Derived from the Milk of Hyperimmunised Cows Suppresses Inflammation by Inhibiting Neutrophil Emigration,” Agents Actions 37, p. 70-79, 1992.
Ormond, D. et al., “Milk from Hyperimmunized Dairy Cows as a Source of a Novel Biological Response Modifier,” Agents Actions 38, p. C146-C149, 1993.
Ormond, D. et al., “The Anti-Inflammatory Activity of a Low Molecular Weight Component Derived from the Milk of Hyperimmunized Cows,” Agents Actions 32, p. 160-166, 1991.
Owens, W. E., et al., “Effect of a Milk-Derived Factor on the Inflammatory Response toStaphylococcus aureusIntramammary Infection,” Vet Immunol Immunopathol 30, p. 233-246, 1992.
Owens, W. E., et al., “Evaluation of an Anti-Inflammatory Factor Derived from Hyperimmunized Cows1(42832),” P.S.E.B.M. 190, p. 79-86, 1989.
Saxon, A., “Oral Administration of Bovine Colostrum Anti-Cyptosporidia Antibody Fails to Alter the Course of Human Cryptosporidiosis,” J Parasit 73:2, p. 413-415, 1987.
Sharpe, S., et al., “Cholesterol-Lowering and Blood Pressure Effects of Immune Milk1-3, ” Am J Clin Nutr 59, p. 929-934, 1994.
Stelwagen K., et al., “An Anti-Inflammatory Component Derived from Milk of Hyperimmunised Cows Reduces Tight Junction Permeability in vitro,” Inflamm Res 47, p. 384-388, 1998.
Stephan H. et al., “Antibodies form Colostrum in Oral Immunotherapy,” J. Clin Chem Biochem 28, p. 19-23, 1990.
Tacket, C., et al., “Efficacy of Bovine Milk Immunoglobulin Concentrate in Preventing Illness After Shigella Flexneri Challenge,” Am J Trop Med Hyg 47:3, p. 276-283, 1992.
Tacket, C., et al., “Protection by Milk Immunoglobin Concentrate Against Oral Challenging with EnterotoxigenicEschericha coli,” N Engl J Med 318:19, p. 1240-1243, 1988.
Tockman, M. et al., “Milk Drinking and Possible Protection of the Respiratory Epit
Humanetics Corporation
Leary Louise N.
Sherrill Law Offices PLLC
Ware Deborah K.
LandOfFree
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