Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1981-04-09
1984-01-10
Roberts, Elbert L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
206 44R, A61K 3156
Patent
active
044253397
ABSTRACT:
A method for treating menopausal symptoms and a pharmaceutical package for effecting the method are disclosed. The method comprises a three phase sequence of estrogen and progestogen administration and an additional drug-free fourth phase during at least one menstrual cycle as follows:
(a) as phase one, 0.2 mg to 1.5 mg of estrone, (or of other natural estrogen in an amount sufficient to result in an effect equivalent to the selected amount of estrone within the aforegiven range) for 4-9 days, followed by
(b) as phase two, 0.2 mg to 1.5 mg of estrone, (or of other natural estrogen in an amount sufficient to result in an effect equivalent to the selected amount of estrone within the aforegiven range), plus 0.2 to 1.5 mg of norethisterone (or of other styptic progestogen, in an amount sufficient to result in an effect equivalent to the selected amount of norethisterone within the aforegiven range); with the proviso that the dosage levels of estrogen and progestogen be approximately equal (as defined in terms of estrone and nonethisterone above); for 6-11 days, followed by
(c) as phase three, twice the dosage of estrogen and twice the dosage of progestogen used in phase two, for at least 6 days, or for an arbitrarily selected greater number of days to a maximum of 90 days; followed by
(d) as phase four, no therapeutically active dosage, i.e., either no treatment or a placebo, for 6-8 days.
REFERENCES:
patent: 3568828 (1971-03-01), Lerner
patent: 3608075 (1971-09-01), Glen
patent: 3932635 (1976-01-01), Segre
patent: 3957982 (1976-05-01), Lachnit-Fixson et al.
patent: 4145416 (1979-03-01), Lachnit-Fixson et al.
patent: 4145416 (1979-03-01), Lachnit-Fixson et al.
Krubiner Alan M.
Moran Tom M.
Roberts Elbert L.
Syntex (U.S.A.) Inc.
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