Treatment of melanoma with a vaccine comprising irradiated autol

Details Treatment of melanoma with a vaccine comprising irradiated autol Treatment of melanoma with a vaccine comprising irradiated autol

1992-12-04

1994-03-01

Parr, Margaret

Drug, bio-affecting and body treating compositions

Lymphokine

424 852, A61K 3900, A61K 3766

Patent

active

052905519

ABSTRACT:
The invention is a haptenized tumor vaccine for the treatment of cancer. Treatment of cancer patients with an autologous, vaccine preceded by low dose cyclophosphamide (CY) induces delayed-type hypersensitivity (DTH) to melanoma cells, and in some cases, regression of metastatic tumors. The efficiency of the process has been increased by immunizing with tumor cells conjugated to the hapten such as DNP, TNP or AED.
Additional embodiments of the vaccine include: 1) combining the vaccine with immunomodulating drugs, such as, interleukin-2 (IL2); and 2) purifying the active components of the vaccine by extracting antigens from cancer cells to produce a chemically-defined, haptenated vaccine. The treatment may also be extended to include other types of human cancer.

REFERENCES:
patent: 4108983 (1978-08-01), Wallack
Bystryn, J-C., Journal of Immunology, vol. 120 (1), pp. 96-101, (1978).
Mitchison, Transplant. Proc. 2:92-103 (1970).
Fujiwara et al., J. Immunol. 132:1571-1577 (1984a).
Flood et al., J. Immunol. 138:3573-3579 (1987).
Fujiwara et al., J. Immunol. 133:510-514 (1984b).
Berd et al., Cancer Res. 42:4862-4866 (1982).
Berd et al., Cancer Res. 44:1275-1280 (1984a).
Berd et al., Cancer Res. 46:2572-2577 (1986).
Berd et al., Cancer Invest. 6:335-347 (1988a).
Berd et al., Cancer Res. 44:5439-5443 (1984b).
Berd et al., Cancer Res. 47:3317-3321 (1987).
Berd et al., Cancer Res. 48:1671-1675 (1988b).
Berd et al., Proc. Amer. Assoc. Cancer Res. 29:408 (#1626) (1988c).
Topalian et al., J. Clin. Oncol. 6:839-853 (1988).
Lotze et al., J. Biol. Response 3:475-482 (1982).
West et al., New Engl. J. Med. 316:898-903 (1987).
Talmadge et al., Cancer Res. 47:5725-5732 (1987).
Meuer et al., Lancet 1:15-18 (1989).
Miller and Claman, J. Immunol. 117:1519-1526 (1976).

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