Treatment of mammals suffering from damage to the central nervou

Details Treatment of mammals suffering from damage to the central nervou Treatment of mammals suffering from damage to the central nervou

1988-02-01

1989-08-08

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514215, 514255, 514263, 514385, 514964, A61K 31155, A61K 3155, A61K 31495, A61K 3152

Patent

active

048553255

ABSTRACT:
A method and compositions, for treating an animal with an injured spinal cord, causing loss to sensory function and motor control, to regain such function and control. The method comprises the administration of a guanidine compound and a serotonergic receptor agonist or a dopaminergic receptor agonist, and preferably a combination with an anti-desensitization agent, such as a xanthine, a b-adrenergic receptor agonist or a vascular skeletal muscle dilator. The composition comprises a guanidine compound and a second compound acting in conjunction therewith or preventing desensitization thereof.

REFERENCES:
Chem. Abst. 98:192,204n, 1983; 100:168, 888c, 1984; 101:2122u, 1984.
Naftchi, Science, pp. 1042-1044, vol. 217, 1982.

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