Treatment of malignant tumors with 2-(.beta.-D-ribofuranosylthia

Details Treatment of malignant tumors with 2-(.beta.-D-ribofuranosylthia Treatment of malignant tumors with 2-(.beta.-D-ribofuranosylthia

1985-02-27

1987-07-14

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 53, 536 55, 536 187, A61K 3170, C07H 500

Patent

active

046802851

ABSTRACT:
The compound 2-.beta.-D-ribofuranosylthiazole-4-carboxamide is used to treat malignant tumors in warm blooded animals. Esters of this compound such as 2-(2,3,5-tri-O-acetyl-.beta.-D-ribofuranosyl)thiazole-4-carboxamide and 2-(5-O-phosphoryl-.beta.-D-ribofuranosyl)thiazole-4-carboxamide are also useful for treating tumors in warm blooded animals.

REFERENCES:
patent: 4309419 (1982-01-01), Wolberg et al.
Fuertes et al., Journal of Organic Chemistry, 1976, vol. 41, No. 29, pp. 4074-4077.
Srivastava et al., Journal of Medicinal Chemistry, 1977, vol. 20, No. 2, pp. 256-262.
Johnson, et al., Cancer Treatment Reviews (1975) 2, 1-31.

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