Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1997-03-10
1999-05-25
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514178, 5142362, 514470, 514565, 514668, A61K 3156, A61K 31535, A61K 3134, A61K 31195, A61K 3113
Patent
active
059069872
ABSTRACT:
The symptoms of climacterium in male mammals, e.g., hypertension, cardiovascular disease and osteoporosis, are ameliorated by the administration to an afflicted individual one or both of a nitric oxide substrate and/or nitric acid donor, in combination with an androgen, an aromatase inhibitor or both, wherein the circulating levels of testosterone in the afflicted individual are increased.
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Garfield et al., "Reversal of Preeclampsia Symptoms Induced in Rats by Nitric Oxide Inhibition With L-Arginine, Steroid Hormones and an Endothelin Antagonist," Soc. Gynecol. Invest. Abst. P384 (1994).
Chwalisz et al., "Estradiol Inhibits the Onapristone-Induced Preterm Parturition in Guinea Pigs by Blocking Cervical Ripening," J. Soc. Gynecol. Invest., vol. 2, No. 2, Mar. 1995., P101.
Chwalisz et al., "Role of Progesterone During Pregnancy: Models of Parturition and Preeclampsia," Z. Geburtshilfe Perinatol, vol. 198, No. 5-5, pp. 170-180, 1994.
Richard et al., "Vivo Evidence of an Endothelin-Induced Vasopressor Tone After Inhibition of Nitric Oxide Synthesis in Rats," Circulation, vol. 91, No. 3, pp. 771-775, Feb. 1995.
Yallamapalli et al., Inhibition of Nitric Oxide Synthesis in Rats During Pregnancy Produces Signs Similar to Those of Preeclampsia, Am J Obstet. Gynecol, vol. 169, No. 5, pp. 1316-1320, 1993.
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Chwalisz Kristof
Garfield Robert E.
Jordan Kimberly
Schering Aktiengesellschaft and Board of Regents
The University of Texas System
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