Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1982-03-17
1983-11-22
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, A61K 3700, C07C10352
Patent
active
044168721
ABSTRACT:
A novel treatment has been discovered for interrupting the life cycle of malaria parasite during its development in the liver of the vertebrate host. The subject invention involves a method of chemotherapy against sporozoite-induced malaria by administering an 8-aminoquinoline drug, such as primaquine, encapsulated within liposomes containing glycoconjugates, to a vertebrate host which has been infected with sporozoites of the parasites. Preferred species of glycoconjugates have a terminal glucose or galactose moiety, such as present in glycosyl ceramide, galactosyl ceramide, lactosyl ceramide, or in glycoproteins.
REFERENCES:
patent: 3993754 (1976-11-01), Rahman et al.
patent: 4224179 (1980-09-01), Schneider
Chem. Abstr., vol. 94, (1981), 132282u.
Chem. Abstr., vol. 94, (1981), 10994g.
Chem. Abstr., vol. 96, (1982), 45906y.
Alving Carl R.
Steck Edgar A.
Bellamy Werten F. W.
Gapcynski William G.
Phillips Delbert R.
Spechler Arthur I.
The United States of America as represented by the Secretary of
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