Treatment of iodine deficiency diseases

Details Treatment of iodine deficiency diseases Treatment of iodine deficiency diseases

1997-12-08

2000-02-01

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

424667, 424899, A01N 5922, A61K 3336

Patent

active

060199709

ABSTRACT:
This invention relates to a composition for use in the treatment or prevention of iodine deficiency diseases or disorders such as fibrocystic dysplasia of the breast, breast cancer, endometriosis, ovarian cysts and premenstrual syndrome. More particularly, this invention relates to a composition for the treatment or prevention of iodine deficiency diseases or disorders, the composition comprising elemental iodine (I.sub.2) which may also be referred to as metallic iodine or iodine metal. The elemental iodine can be used with any pharmaceutically acceptable carrier.

REFERENCES:
patent: 59756 (1866-01-01), Benedict
patent: 1580400 (1926-04-01), Bommarito
patent: 2022729 (1935-12-01), Malisoff
patent: 2385394 (1945-04-01), Witte
patent: 2816854 (1957-12-01), Gross
patent: 2927058 (1960-03-01), Minto
patent: 3881991 (1975-05-01), Kurimoto et al.
patent: 3888739 (1975-06-01), Whetzel et al.
patent: 4010259 (1977-03-01), Johansson
patent: 4012504 (1977-03-01), Eckols
patent: 4187294 (1980-02-01), Ishikawa et al.
patent: 4230503 (1980-10-01), Hughes
patent: 4259322 (1981-03-01), Lim
patent: 4279940 (1981-07-01), Wurzburg et al.
patent: 4338304 (1982-07-01), Kamimae et al.
patent: 4384960 (1983-05-01), Polley
patent: 4394376 (1983-07-01), Kamimae et al.
patent: 4555347 (1985-11-01), O'Dowd et al.
patent: 4564521 (1986-01-01), Altadonna
patent: 4729948 (1988-03-01), Saruhashi et al.
patent: 4737459 (1988-04-01), Zeikus et al.
patent: 4744975 (1988-05-01), Suami et al.
patent: 4755397 (1988-07-01), Eden et al.
patent: 4816255 (1989-03-01), Ghent et al.
patent: 4867967 (1989-09-01), Crutcher
patent: 4886661 (1989-12-01), Guy et al.
patent: 5171582 (1992-12-01), Ghent et al.
patent: 5250304 (1993-10-01), Ghent et al.
patent: 5389385 (1995-02-01), Ghent et al.
patent: 5589198 (1996-12-01), Eskin et al.
Amalric, R. et al., "Dysplasies Fibro-Kystiques Aspects Thermographiques et Radiographiques" Senologia, 1977, 2:45-51.
Beatson, G. T., On the Treatment of Inoperable Cases of Carcinoma of the Mamma: Sugestions for a New Method of Treatment with Illustrative Cases. Lancet 2, 1986, pp. 162-165.
Bloomer et al., "Estrogen receptor-mediated cytotoxicity using iodine-125" J. Cell. Biochem. (1983) 21:39-45.
Bloomer et al., "Estrogen receptor-mediated cytotoxicity using iodine-125" Chem. Abstracts (1983) 99:(Abstract No. 136212x).
Bloomer et al., "Iodine-125-labelled tamoxifen is differrently cytotoxic to cells containing oestrogen receptors" Int. J. Radiat. Biol. (1980) 38(2):197-202.
Bloomer et al., "Iodine-125-labelled tamoxifen is differrently cytotoxic to cells containing oestrogen receptors" Chem. Abstracts (1981) 94:(Abstract No. 94:41160m).
Bluhm et al., "Detailed structure of the V.sub.h -amylose-iodine complex: a linear polyiodine chain" Carbohydrate Research (1981) 89:1-9.
Cole, E. N., R. A. Gillwood et al., "Serum Prolactin Concentrations in Benign Breast Disease Throughout the Menstural Cycle" Europ. J. Cancer, 13:597-603.
Derwent Patent Database Abstract of Russian Patent No. 197385 to Mokhnach (May 31, 1967), 1 page total.
Dyer "An Index of Tumor Chemotherapy" N.I.H. (1949) pp. 10-12, 22, 23.
Eskin et al., "Etiology of mammary gland pathophysiology induced by iodine deficiency" Frontiers in Thyroidiology (1986) G. Medeiros-Neto and E. Gaitan (eds.), Plenum Medical Book Company, New York 2:1027-1031.
Eskin et al., "Human breast uptake of radioactive iodine" Obstetrics and Gynecology (1974) 44(3): 398-402.
Eskin et al., "Replacement therapy with iodine in breast neoplasia" Intl. J. Gynecol. Obstet. (1970) 8(2):232(Abstract No. 354).
Eskin, "Iodine metabolism and breast cancer" Chem. Abstracts (1971) 75:237 (Abstract No. 17655p).
Eskin, "Iodine metabolism and breast cancer" Trans. N.Y. Acad. Sci. (1970) 32(8):911-947.
Eskin, B.A., "Iodine and mammary cancer" Adv. Exp. Med. Biol. (1978) 91:293-304.
Eskin, B.A., "Iodine and mammary cancer" Chem. Abstracts (1979) 90:337 (Abstract No. 135752a).
Eskin., "Iodine and breast cancer--a 1982 update" Biological Trace Element Research (1983) 5:399-412.
Eskin., "Thyroid hormones and tumor development" Influences of Hormones in Tumor Development (1979) Franklin Publishers, (Chapter 6) pp. 130-156.
Fiedler, Lexicon der Hilstoffe (1989) p. 152-153. A partial English Abstract is also enclosed.
Fratkin. L. B., "The Hyperestrogen State" Paper Presented at the North Pacific Surgery Meeting<Tacoma, Washington, 1980, (unpublished).
Gairard, B. et al., "Proteins and Ionic Components in the Breast Cyst Fluid", Endocrinology of Cystic Breast Disease, Rave Press, 1983, 191-195.
Ghent et al., "Fibrocystic breast dysplasia: A deficiency syndrome" Clin. Invest. Med. (Canada) (1986)9(3):A66(Abstract No. R-406).
Ghent, "Elemental iodine supplementation in clinical breast dysplasia" Proc. 77th Annual Meeting Amer. Assoc. Cancer Res. (1986) 27:189(Abstract No. 751).
Greenblatt, R. B. et al., "Canazol in the Treatment of Mammary Dysplasia" Fertility and Sterility, 1980, 34:242-245.
Gros, C., et al., "Classification Thermographique Des Cancers Mammaires" Bull Cancer, Paris, 58:351-362, 1971.
Haagensen, C. D., "Disease of the Breast" 2nd Edition, W.B. Saunders, 1971, 380-383.
Handa et al., "On the blue color of triiodide ions in starch and starch fractions. II. Characterization of the changes in absorption and circular dichroism spectra of triiodide iocns in amylose with the DP" Biopolymers (1980) 19:723-740.
Harrison's Principles of Internal Medicine, (1984) Isselbacher et al., (eds.)13th edition, Part 5: Nutrition, Table 71-4.
Hatch, "Effect of temperature on the starch-iodine spectrophotometric calibration line" Anal. Chem. (1982) 54(12):2002-2005.
Hetzel, "Iodine deficiency disorders (IDD) and their eradication" Lancet (1983) 12:1126-1129.
Honour et al., "Secretion of radioiodine in digestive juices and milk in man" Clin. Science (1952) 11:447-462.
Kelly et al., "Prevalence and geographical distribution of endemic goitre" W.H.O. Monograph, 44: 27-35.
Kemp et al., Organic Chemistry (1980) Worth Publishers, Inc., Chapter 27, pp. 992-994.
Larson et al., "Amperometric method for determining the sorption of iodine by starch" Anal. Chem. (1953) 25:802-804.
Martindale, The Extra pharmacopoeia, 29th Edition, (1989) Reynolds (ed.), The Pharmaceutical Press, London, p. 1185.
Minton, J. P. et al., "Caffeine, Cyclic Cucleotides and Breast Disease" Surgery, 86:105-109, 1979.
Moss, A. A. et al., "Fluorescent Excitation Analysis: A Simplified Method of Iodine Determination in Vitro" Investigative Radiology, 7:335-338, 1972.
Moossa et al., "Thyroid status and breast cancer" Ann. Roy. Coll. Surg. Engl. (1973) 53:178-188.
Peacock, Jr., Erlee, "Management of Benign Disease of the Breast" American Surgeon, 1978, 44(10):626-630.
Riggs, D. S. et al, "Investigations on the Nature of Blood Iodine".
Pennington, "A review of iodine toxicity reports" Journal of the American Dietetic Association (1990) 90:1571-1581.
Roberts, M. M. et al., "Risk of Breast Cancer in Women with History of Benign Disease of the Breast," British Medical Journal, Jan. 28, 1984, 288:275-278.
Robyt, "In vivo conversion of starch to D-glucose" Starch Chemistry and Technology, pp. 106-108.
Song et al., "Resistance of the Giarda lamblia cysts to various disinfectants" Chem. Abst. (1984) 101:389-390(Abstract No. 126735r).
Spratt, J. S. et al., "Association of Chronic Cystic Mastopathy" Xeromammographic Patters and Cancer, (prepublication).
Stringer et al., "Comparison of bromine, chlorine & iodine as disinfectants for amoebic cysts" Disinfection--Water & Wastewater (1975), pp. 193-209.
Stringer et al., "Comparison of bromine, chlorine & iodine as disinfectants for amoebic cysts" Chem. Abstracts (1976) 84:299 (Abstract No. 126316k).
Strum et al., "Resting human female breast tissue produces iodinate protein" J. Ultrastructure Res. (1983) 84:130-139.
Takeda et al., "Structures and amounts of branched molecules in rice amyloses" Carbohydrate Research (1989) 186:163-166.
Takeda et al., "Structures of indica rice starches (IR48 and IR64) having intermediate affinities for iodine" Carbohydrate Research (1989) 187:287-294.
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