Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Patent
1994-06-08
1998-03-24
Loring, Susan A.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
4241411, 4241581, 4241841, 4241451, 424 851, 4241431, 4241921, 514263, 514264, 514929, 530351, 53038823, C07K 1624, C07K 1452, A61K 3811, C07H 1900
Patent
active
057309752
ABSTRACT:
An induction of TNF-.alpha. mRNA expression has been observed in adipose tissue from four different insulin resistant rodent models of obesity and diabetes. TNF-.alpha. protein was also elevated locally and systemically. Neutralization of TNF-.alpha. in obese fa/fa rats caused a significant increase in the peripheral uptake of glucose in response to insulin. A method of treating an animal suffering from insulin resistance in obesity linked Type II diabetes mellitus is disclosed. The method includes providing a therapeutic agent that includes an antagonist to TNF-.alpha. function in a pharmaceutically acceptable carrier substance and administering a pharmacologically effective amount of the therapeutic agent to the animal.
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Hotamisligil Gokhan S.
Spiegelman Bruce M.
Dana-Farber Cancer Institute Inc.
Loring Susan A.
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