Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Reexamination Certificate
2007-11-20
2011-10-04
Desai, Anand (Department: 1656)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
C424S078080, C514S002600
Reexamination Certificate
active
08030442
ABSTRACT:
Methods and compositions that inhibit acid sensing ion channels are provided for the prevention and treatment of brain injury, including injury caused by stroke or seizure. The methods and compositions of the invention are additionally effective for the reduction of acidosis in the brain.
REFERENCES:
patent: 2007/0232540 (2007-10-01), Simon et al.
patent: 2008/0279965 (2008-11-01), Simon et al.
patent: 01/85931 (2001-11-01), None
patent: 2006/034035 (2006-03-01), None
International Search Report (PCT/US05/33171)—Aug. 18, 2006.
Aarts, et al., (2004), “Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor-PSD-95 Protein Interations”, vol. 298, Science Magazine, pp. 846-850.
Xiong, et al., (2004), “Neuroprotection in Ischemia: Blocking Calcium-Permeable Acid-Sensing Ion Channels”, Cell, vol. 118, pp. 687-698.
Bladin, et al., (2000) “Seizures After Stroke—A Prospective Multicenter Study”, Arch Neurol. vol. 57, pp. 1617-1622.
Anderson, et al., (2002), “Protection of Focal Cerebral Ischemia by Alkalinazation of Systematic pH”, Neurosurgery 51:1258-1266.
Simon Roger P.
Xiong Zhi-Gang
Andrews & Kurth LLP
Desai Anand
Morehouse School of Medicine
Wang Ping
LandOfFree
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