Treatment of inflammatory bowel diseases with anti-IP-10...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C424S139100

Reexamination Certificate

active

07935793

ABSTRACT:
The present invention is directed to high affinity anti-human IP-10 antibodies or antigen-binding fragments of these antibodies, including chimeric, humanized or fully human antibodies. The present invention is also directed to a method of reducing the severity of at least one symptom of an inflammatory bowel disease in a subject in need thereof comprising administering to said subject an effective amount of an antagonist of IP-10, including the antibodies or antibody fragments of the present invention.

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Singh, Udai P. et al, Inhibition of IFN-γ-Inducible Protein-10 Abrogates Colitis in IL-10%Mice, The Journal of Immunology, vol. 171, pp. 1401-1406 (2003).

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