Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2003-10-15
2008-08-12
Tsang, Cecilia (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S002600, C530S317000, C530S329000
Reexamination Certificate
active
07410945
ABSTRACT:
This invention relates to methods of treatment of inflammatory bowel disease, and especially to treatment of this condition with cyclic peptidic and peptidomimetic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists of the C5a receptor, and are active against C5a receptors on polymorphonuclear leukocytes and macrophages. Particularly preferred compounds for use in the methods of the invention are disclosed.
REFERENCES:
patent: 5807824 (1998-09-01), van Oostrum et al.
patent: 2007/0054841 (2007-03-01), Shiels et al.
patent: WO 9900406 (1999-01-01), None
patent: WO 9900406 (1999-01-01), None
Van Assche G. “Emerging Drugs to Treat Crohn's Disease”, 2007, Expert Opin. Emerging Drugs, vol. 12. pp. 49-59.
Maho Ikeda, et al., Simvastatin Attenuates Trinitrobenzene Sulfonic Acid-Induced Colitis, but Not Oxazalone-Induced Colitis, Springer Science+Business Media, LLC 2007, Oct. 27, 2007, Dig Dis Sci, DOI 10.1007/s10620-007-0102-0.
M. Toulouse, et al., Role of Tachykinin NK2 Receptors in Normal and Altered Rectal Sensitivity in Rats, British Journal of Pharmacology (2000) 129, pp. 193-199, Macmillan Publishers Ltd.
Laurent Diop, et al., Pregabalin (CI-1008) Inhibits the Trinitrobenzene Sulfonic Acid-Induced Chronic Colonic Allodynia in the Rat, The Journal of Pharmacology and Experimental Therapeutics, 2002, pp. 1013-1022, vol. 302, No. 3, http://jpet.aspetjournals.org.
Tetsuya Fukunaga, et al., A Novel Diamino-Pyridine Derivative (IS-741) Attenuates Rat Ileitis Induced by Trinitrobenzene Sulfonic Acid, Journal of Gastroenterology (2003); 38:pp. 451-459, Springer-Verlag 2003.
Gerald P. Morris, et al., Hapten-Induced Model of Chronic Inflammation and Ulceration in the Rat Colon, Gastroenterology (1989) pp. 795-803, vol. 98, American Gastroenterological Association.
Fairlie David
Taylor Stephen Maxwell
Woodruff Trent Martin
Audet Maury
Haynes and Boone LLP
Moore Mark D.
The University of Queensland
Tsang Cecilia
LandOfFree
Treatment of inflammatory bowel disease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatment of inflammatory bowel disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of inflammatory bowel disease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4007992