Treatment of inflammation using 358 substituted alpha-antitrypsi

Details Treatment of inflammation using 358 substituted alpha-antitrypsi Treatment of inflammation using 358 substituted alpha-antitrypsi

1991-01-18

1992-07-28

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530392, 514 12, 514 21, 514 2, A61K 3764, C07K 1514

Patent

active

051341190

ABSTRACT:
A method for the prophylaxis or direct treatment of mast cell implicated skin inflammation in a patient which comprises topically administering an effective amount of an analog of alpha 1-antitrypsin, its salts or derivatives, and compositions thereof.

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patent: 4732973 (1988-03-01), Barr et al.
patent: 4734279 (1988-03-01), Stephan et al.
patent: 4916117 (1990-04-01), Lezdey et al.
Allergy Proc. "The Mast Cell: a comprehensive Update Review" Bernstein et al, Sep.-Oct. 1990, vol. 11, No. 5, pp. 209-223.
Pannuculitis Associated with Severe 1-Antitrypsin Deficiency-Med. Affairs Arch Dermatol vol. 123, Dec. 1987.
Kevin C. Smith et al. Sequence Homology Between Human 1-Antichymotrypsin 1-Antitrypsin and Antithrombin III-Amer. Chem. Soc. vol. 22-No. 22 1983-T. Chandra et al.
Structure, Function, and Control of Neutrophil Proteinases-The American Journal of Medicine-vol. 84-Travis et al pp. 37-42.
J. Amer. Acad. of Dermatology, "The Mast Cell in Health & Disease" Rothe et al, vol. 23, No. 4, Part 1, pp. 615-624, Oct. 1990.
Biochem. Efficacy & Safety of Monthly Augmentation Therapy for Alpha.sub.1 -Antitrypsin Deficiency-Hubbard et al.-Jama, Sep. 2, 1988-vol. 260, No. 9-The Journal of Investigative Dermatology-Mar. 1991-vol. 96 No. 3.

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