Treatment of infertile sperm in vitro with thymosin .alpha..sub.

Details Treatment of infertile sperm in vitro with thymosin .alpha..sub. Treatment of infertile sperm in vitro with thymosin .alpha..sub.

1994-04-15

1996-12-17

Schwadron, Ronald B.

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

4352402, 530324, 530399, 600 33, A01N 102, A61D 1900, A61K 3816, C12N 506

Patent

active

055852343

ABSTRACT:
The present invention relates to a method for increasing penetration of mammalian ova by mammalian male sperm by contacting sperm in vitro with a penetration-enhancing amount of a penetration-enhancing thymosin polypeptide or a penetration enhancing anti-thymosin antibody. In preferred embodiments, treatment comprises contacting mammalian sperm with thymosin .alpha..sub.1 or antibodies to thymosin .alpha..sub.1 or thymosin .beta..sub.4.

REFERENCES:
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Naz et al., Biol. of Reprod., 47:1064-72, 1992.
Milton G. Mutchnick, et al., "Thymosin Treatment Of Chronic Hepatitis B: A Placebo-Controlled Pilot Trial", Hepatology vol. 14, No. 3, 1991, 409 -415.
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Seibel, New England J. Med., vol. 318, No. 13, 1988 pp. 828-834.
Waldmann, Science, vol. 252, 21 Jun., 1991 pp. 1657-1662.
Naz et al., Int J. Fertil., vol. 32, No. 5, 1987 pp. 375-379.

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