Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1995-06-06
1998-01-06
Loring, Susan A.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
4241821, 4241541, 4241791, 5303871, 5303911, 5303913, 5303881, 53038873, 530 3875, 5303917, A61K 39395, A61K 4900, C07K 1618
Patent
active
057051585
ABSTRACT:
A polyspecific anti-leukocyte antibody conjugate for targeting foci of leukocyte accretion comprises an immunoreactive polyspecific composite of at least two different substantially monospecific antibodies or antibody fragments, conjugated to at least one imaging agent, wherein at least two of said antibodies or antibody fragments specifically bind to different leukocyte cell types.
A method for targeting an imaging agent to an inflammatory or infectious lesion comprises injecting a mammal parenterally with an effective amount for targeting of the above anti-leukocyte imaging conjugate.
A therapeutic anti-leukocyte antibody-agent conjugate for targeting foci of leukocyte accretion comprises at least one immunoreactive substantially monospecific antibody or antibody fragment which specifically binds to at least one leukocyte cell type, conjugated to at least one therapeutic antimicrobial agent.
A method of treatment of an infectious lesion comprises injecting a mammal parenterally with an effective amount for therapy of the above anti-leukocyte therapeutic conjugate.
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Koizumi, M. et al, Cancer Research, 48:1189-1194, Mar. 1, 1988.
Goodman & Gilman, The Pharmacological Basis of Therapeutics, 6th ed., Eds. pp. 1080-1248, Macmillan Publishing Co, N.Y, 1980.
Goldenberg Milton David
Hansen Hans John
Immunomedics Inc.
Loring Susan A.
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