Treatment of iatrogenic and age-related hypertension and pharmac

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514567, A61K 3144, A61K 31195

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active

060515872

ABSTRACT:
Hypertension in mammalian patients, especially elderly human patients, derived from ingestion of NSAIDs or through the normal aging process is treated by administration to the patient of a vitamin B.sub.6 (or derivative) supplement. Where the patient requires the continued administration of an NSAID for pharmacological purposes, the NSAID is administered in conjunction with a vitamin B.sub.6 supplement. The invention further provides combination pharmaceutical combinations of an NSAID and a vitamin B.sub.6 supplement, e.g. orally administrable tablets or capsules, for use in treating such conditions.

REFERENCES:
patent: 4374841 (1983-02-01), Deschamps et al.
patent: 4564614 (1986-01-01), Crawford et al.
The Effects of Vitamin B6 on the Systolic Blood Pressure of Rats in Various Animal Models of Hypertension, Lal et al., Journal of Hypertension 1996, vol. 14, No. 3, 355-362.
Hypotensive Action of 5-HT Receptor Agonists in the Vitamin B6-Deficient Hypertensive Rat, Lal et al., European Journal of Pharmacology, 234(1993) 183-189.
Sympathetic Stimulation and Hypertension in the Pyridoxine-Deficient Adult Rat, Paulose et al., Journal of Hypertension, 1988, vol. 11, No. 4, 387-391.
Calcium Channels in Vitamin B6 Deficiency-Induced Hypertension, Lal et al., Journal of Hypertension 1993, vol. 11, No. 12, 1357-1362.

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