Treatment of hypertrophic wound healing disorders with calcium c

Details Treatment of hypertrophic wound healing disorders with calcium c Treatment of hypertrophic wound healing disorders with calcium c

1990-12-17

1992-07-21

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Heavy metal or compound thereof

514277, 514356, 514523, 514947, A61K 31275, A61K 3144, A61K 3324

Patent

active

051321190

ABSTRACT:
This invention pertains to a method for controlling hypertrophic wound healing disorders by administering calcium channel blockers to the wound site. Calcium channel blockers are found to regulate fibroblast biosynthesis and can therefore be used to therapeutically control diseases characterized by excessive fibroblast biosynthesis.

REFERENCES:
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Askey, D. B. et al., Proceedings Electrochemical Society, Los Angeles, Calif., May 7-12, 1989.
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McLeod, K. J. et al., Science 236:1465-1469 (1987).
Abergel, R. P. et al., J. Invest. Dermatol. 84:384-390 (1985).
Miller, E. A., "Electric Field Modulation of Exocytosis in Human Fibroblasts", S.B. Thesis, M.I.T. (1987).
Sank, A. et al., Surgery 106:1141-1148 (Dec. 1989).
Steinleitner, A. et al., J. Reproductive Medicine, 33:891-894 (Nov. 1988).
Block, L. H. et al., Proc. Natl. Acad. Sci. USA 86:2388-2392 (Apr. 1989).
Lee, R. C. and J. Ping, J. Surg. Res. 49:463-466 (1990).

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