Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1983-12-09
1990-02-06
Michl, Paul R.
Drug, bio-affecting and body treating compositions
Lymphokine
424 78, 5142232, 5142235, 514629, 514651, 514653, 514869, A61K 3179
Patent
active
048987298
ABSTRACT:
Antihypertension action is achieved without diuresis by administration of a thiazide diuretic in an amount which while being sufficient to achieve antihypertension is insufficient to achieve diuresis. Such administration in a non-diuretic amount is effected in 4-8 consecutive hourly doses to achieve reduction of blood pressure without high urine output. The invention further relates to complexes of thiazides with mixed cation-anion exchange resins, to insoluble basic metal hydroxy thiazide salts, the salts of thiazide with calcium disodium edetate or disodium edetate, to molecular complexes of thiazides with long chain polymers such as hydroxy alkyl cellulose polymers, carboxy methyl cellulose and polyvinylpyrrolidone, to beta-adrenergic blocking amine-thiazide salts and to amiloride thiazide salts.
REFERENCES:
patent: 3476858 (1969-11-01), Nelson
patent: 3781430 (1973-12-01), Cragoe
Diuretics Chemistry, Pharmacology, and Medicine, Edited by Edward J. Cragoe, Jr., John Wiley & Sons, 1983, pp. 76-97, 689, 690.
Handbook of Hypertension, vol. 1, Clinical Aspects of Essential Hypertension, edited by J. I. S. Robertson, Elsevier, 1983, pp. 404-409.
Halpern Alfred
Hofer Peter
Leslie Stewart
Miller Ronald B.
Euroceltique S.A.
Michl Paul R.
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