Treatment of hyperlipoproteinemia with a dichloroacetate salt

Details Treatment of hyperlipoproteinemia with a dichloroacetate salt Treatment of hyperlipoproteinemia with a dichloroacetate salt

1977-08-29

1978-10-24

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

A61K 3119

Patent

active

041221885

ABSTRACT:
The present invention relates to the use of salts of dichloroacetate which contain one or two molecules of dichloroacetate and one or two atoms of a mono- or divalent metallic cation, and particularly sodium dichloroacetate, for the treatment of hyperlipoproteinemia in humans.
The method of this invention has utility in the treatment of conditions in a human patient-subject in which there is abnormal elevation of the blood levels of one or more of the major lipids (cholesterol and triglycerides) normally present in the body.

REFERENCES:
patent: 3179562 (1965-04-01), Hoffman et al.
Chem. Abst. 84, 159,601(c) - Holloway et al., - "Phenformin . . . Dichloroacetate" (1976).
Chem. Abst. 83, 25,895(x) - Blackshear et al., "Metabolic Interaction of Dichloroacetate . . . Ketoacidosis" (1975).
Chem. Abst. 82, 68,815(t) Blackshear et al., "Metabolic Effects of Sodium Dichloroacetate . . . Rat" (1975).
Chem. Abst. 72, 77261(e) - Stacpoole et al. (1970).

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