Treatment of hyperandrogenic conditions

Details Treatment of hyperandrogenic conditions Treatment of hyperandrogenic conditions

1996-10-24

1998-05-26

Rothman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 262, 536 2626, 5462811, 5462831, C07H 1904, C07H 19048, A61K 31705

Patent

active

057564809

ABSTRACT:
The invention concerns the treatment of hyperandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5.alpha.-reductase enzymes from 3-oxo-4-oxa end 4-thiasteroids having a 1,2-double bond and the pyridine-nucleotide cofactor of the 5.alpha.-reductase enzyme, NADPH. The invention further relates to the isolated inhibitor-cofactor complex.

REFERENCES:
patent: 3644421 (1972-02-01), Cross
patent: 4760071 (1988-07-01), Rasmusson et al.
patent: 5075450 (1991-12-01), Rasmusson et al.
patent: 5084574 (1992-01-01), Bhattacharya et al.
patent: 5091380 (1992-02-01), Rasmusson et al.
Wall Street Journal, May 7, 1996, p. B4, "Study finds Abbott's prostate drug is much more effective than Merck's ".
The Daily, Tuesday, May 7, 1996, "New data on Proscar, Abbott's Hytrin show conflicting results".
Tian et al., Biochemistry, vol. 33 (1994), pp. 2291-2296, "17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-androstan-1-en-3-one is an active site-directed slow time-dependent inhibitor of human steriod 5alpha-reductase 1".
Everse et al., Bioorganic Chemistry, vol. 1 (1971), pp. 207-233, "Addition products of diphosphopyridine nucleotides with substrates of pyridine nucleotide-linked dehydrogenases".
Bull et al., J. Am. Chem. Soc., vol. 118 (1996), pp. 2359-2365, "Mechanism-based inhibition of human steroid 5alpha-reductase by finasteride".
Faller et al., Biochemistry, vol. 32 (1993), pp. 5705-5710, "Finasteride: A slow-binding 5alpha-reductase inhibitor".
Baginsky et al., FASEB J., vol. 8 (1994), p. 638, "Mechanism of inhibition of human prostatic 5alpha-reductase by 4-azasteroids".
Barton et al., J. of the Chem. Soc., Perkin Trans. 1, No. 8 (1982), pp. 1919-1922, "Dehydrogenation of lactones using benzeneseleninic anhydride."
Barton et al., Tetrahedron Letters, No. 35 (1979), pp. 3331-3334, "Preparation of aldehydes and ketones by oxidation of benzylic hydrocarbons with benzeneseleninic anhydride."

Affiliated with

Also associated with

Rating

Treatment of hyperandrogenic conditions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment of hyperandrogenic conditions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of hyperandrogenic conditions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1960209