Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1987-10-20
1989-05-23
Rollins, John W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 51, 424451, 424464, 536 23, A61K 3170, A61K 900, A61K 922
Patent
active
048331309
ABSTRACT:
Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof.
Also disclosed is the use of the 5'-mono, di- and triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof for the same purpose.
REFERENCES:
Ostertag et al., PNAS 71:4980-4985, 1974.
Mitsuya et al., PNAS 82:7096-7100, 1985.
Riesenberg JAMA 254:2521, 2527, 2529, 1985.
Chem. Eng. News. 64: 28-40, 1986.
FDA Bull. 15: 27-32, 1985.
The Lancet, 1: 957-958 1987.
Krieg et al., Exp. Cell Res. 116: 21-29, 1978.
Lin et al., J Med Chem., 26: 1691-1696, 1983.
DeClerge et al., Biochem. Phem., 29: 1849-1851 1980.
Barry David W.
Furman Phillip A.
Lehrman Sandra N.
Rideout Janet L.
St. Clair Martha H.
Brown Donald
Burroughs Wellcome Co.
Nielsen Lawrence A.
Rollins John W.
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