Treatment of human viral infections

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 50, 514261, 424 852, A01N 4304, A01N 4390, A61K 4505

Patent

active

058771638

ABSTRACT:
A method of treating AIDS with 3'-azido-3'-deoxythymidine in combination with interleukin II or phosphonoformate is presented.

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patent: 4874609 (1989-10-01), Rideout et al.
Antonella Surbone, M.D., "Treatment of the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Relatee Complex with a Regimen of 3'-Azido-2',3'-Dideoxythymidine (Azidothymidine or Zidovudine) and Acyclovir," Annals of Internal Medicine, 1988; 108: pp. 534-540.
Anthony W. Schrecker, "Inhibition of RNA-dependent DNA Polymerase by Thymidylate Derivatives.sup.1," Cancer Research, 32, pp. 1547-1553, July 1972.
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FDA Drug Bull., vol. 15, NR 3, Oct. 1985, pp. 27-32.
"Zidovudine (AZT)," The Lancet, NR 8539, Apr. 25, 1997, pp. 957-958.
Donald E. Riesenberg, MD, "Anti-AIDS agents show varying early results in vitro and in vivo," JAMA (Medical News) Nov. 8, 1995--vol. 254, No. 18.
Hiroaki Mitsuya, "3'-Azido-3'-deoxythymidine (BW A509U): An antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro," Proc. Natl. Acad. Sci USA, vol. 82, pp. 7096-7100, Oct. 1985.
Robert Yarchoan, et al., "Adminstration of 3'-Azido-3'-Deoxythymidine, an Inhibitor of HTLV-III/LAV Replication, to Patients With AIDS or AIDS-Related Complex," The Lancet, Mar. 15, 1986, pp. 575-580.
Craig et al. "Modern Pharmacology", 3rd efition. (1990) (Little, Brown and Co.: Boston) p. 385, 1990.

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