Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1987-10-21
1989-04-04
Rollins, John W.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424451, 424464, 424DIG15, 514 50, 514960, 514962, 514966, 514967, 604415, A61K 948, A61K 944
Patent
active
048185388
ABSTRACT:
Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof.
Also disclosed is the use of the 5.dbd.-mono-, di- and triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof for the same purpose.
REFERENCES:
Imazawa, J. Org. Chem. 43(15): 3044, 3048, 1978.
Horwitz, J. Org. Chem. 29:2076-2078, 1964.
Glinski, J. Org. Chem. 38(25): 4299-4305, 1973.
Shannon, Science 284: 472-507, 1977.
DeClercq et al., Biochem Pharm., vol. 29, pp. 1849-1851, 1980.
Lin et al., J. Med. Chem., vol. 26: 1691-1696, 1983.
Krieg et al., Exp. Cell Res., vol. 116:21-29, 1978.
Barry David W.
Furman Phillip A.
Lehrman Sandra N.
Rideout Janet L.
St. Clair Martha H.
Brown Donald
Burroughs Wellcome Co.
Nielsen Lawrence A.
Rollins John W.
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