Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1986-08-21
1997-11-04
Rollins, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 51, 514261, 514934, A61K 31705, A61K 3152
Patent
active
056839901
ABSTRACT:
Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof. Also disclosed is the use of the 5'-mono-, di- and triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof for the same purpose. Additionally, there is disclosed the treatment of Kaposi's sarcoma with 3'-azido-3'-deoxythymidine (AZT) and the synergistic activity in the treatment of humans infected with HTLV-III of AZT and interferon as well as AZT and acyclovir and AZT and 2-amino-9-(2-hydroxyethoxymethyl)purine or an ester thereof.
REFERENCES:
patent: 4360522 (1982-11-01), Schaeffer
patent: 4649140 (1987-03-01), Schaeffer
patent: 4710492 (1987-12-01), Lin et al.
patent: 4724232 (1988-02-01), Rideout et al.
patent: 4857511 (1989-08-01), Rideout et al.
Yarchoan et al, Lancel (8481) pp. 575-580, Mar. 1986.
Surbone et al, Anal of Internal Medicine 108 pp. 534-540 (1988).
Barry David Walter
Furman Phillip Allen
Lehrman Sandra Nusinoff
Rideout Janet Litster
St. Clair Martha Heider
Brown Donald
Glaxo Wellcome Inc.
Prus Karen L.
Rollins John
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