Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1987-10-21
1989-05-09
Rollins, John W.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424464, 514 50, 514960, 514962, A61K 944, A61K 3170
Patent
active
048288381
ABSTRACT:
Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof.
Also disclosed is the use of 5'-mono-, di- and triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof for the same purpose.
REFERENCES:
Imazawa, J. Org. Chem., 43(15):3044, 3048, 1978.
Horwitz, J. Org. Chem., 29:2076-2078, 1964.
Glinski, J. Org. Chem., 38(25):4299-4305, 1973.
Shannon, Science, 284:472-507, 1977.
DeClercq et al., Biochem. Pharm., vol. 29:1849-1851, 1980.
Lin et al., J. Med. Chem., vol. 26:1691-1696, 1983.
Krieg et al., Exp. Cell Res., vol. 116:21-29, 1978.
Barry David W.
Furman Phillip A.
Lehrman Sandra N.
Rideout Janet L.
St. Clair Martha H.
Brown Donald
Burroughs Wellcome Co.
Nielsen Lawrence A.
Rollins John W.
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